UniProt Q13564
NEDD8-activating enzyme E1 regulatory subunit (Q13564)
NEDD8-activating enzyme E1 regulatory subunit (UniProt Q13564): 16 experimental structures and 1 predicted model on GenesisL1, 6 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q13564
- Protein
- NEDD8-activating enzyme E1 regulatory subunit
- Experimental structures
- 16
- Predicted models
- 1
- Pockets
- 6 · 1 record with a druggable one
Structures
17 records of Q13564 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1R4M | APPBP1-UBA3-NEDD8, an E1-ubiquitin-like protein complex | x-ray diffraction | A, C, E, G | — | — |
| 1R4M | APPBP1-UBA3-NEDD8, an E1-ubiquitin-like protein complex | x-ray diffraction | A, C, E, G | — | — |
| 1R4N | APPBP1-UBA3-NEDD8, an E1-ubiquitin-like protein complex with ATP | x-ray diffraction | A, C, E, G | — | — |
| 1R4N | APPBP1-UBA3-NEDD8, an E1-ubiquitin-like protein complex with ATP | x-ray diffraction | A, C, E, G | — | — |
| 1YOV | Insights into the Ubiquitin Transfer Cascade from the refined structure of the activating enzyme… | x-ray diffraction | A, C | — | — |
| 1YOV | Insights into the ubiquitin transfer cascade from the refined structure of the activating enzyme… | x-ray diffraction | A, C | — | — |
| 2NVU | Structure of APPBP1-UBA3~NEDD8-NEDD8-MgATP-Ubc12(C111A), a trapped ubiquitin-like protein… | x-ray diffraction | A | — | — |
| 2NVU | Structure of APPBP1-UBA3~NEDD8-NEDD8-mgatp-UBC12(C111A), a trapped ubiquitin-like protein… | x-ray diffraction | A | — | — |
| 3DBH | Structural Dissection of a Gating Mechanism Preventing Misactivation of Ubiquitin by NEDD8's E1… | x-ray diffraction | A, C, E, G | — | — |
| 3DBH | Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8'S E1… | x-ray diffraction | A, C, E, G | — | — |
| 3DBL | Structural Dissection of a Gating Mechanism Preventing Misactivation of Ubiquitin by NEDD8's E1… | x-ray diffraction | A, C, E, G | — | — |
| 3DBL | Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8'S E1… | x-ray diffraction | A, C, E, G | — | — |
| 3DBR | Structural Dissection of a Gating Mechanism Preventing Misactivation of Ubiquitin by NEDD8's E1… | x-ray diffraction | A, C, E, G | — | — |
| 3DBR | Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8'S E1… | x-ray diffraction | A, C, E, G | — | — |
| 3GZN | Structure of NEDD8-activating enzyme in complex with NEDD8 and MLN4924 | x-ray diffraction | A, C | — | — |
| 3GZN | Structure of NEDD8-activating enzyme in complex with NEDD8 and MLN4924 | x-ray diffraction | A, C | — | — |
| Q13564 | AlphaFold monomer V2.0 prediction for NEDD8-activating enzyme E1 regulatory subunit (Q13564) | predicted | A | — | 6 (best 0.60) |
Experiment against prediction
- 3DBH chain A against the predicted model Q13564: TM-score 0.99, RMSD 0.61 Å
- 3DBH chain A against the predicted model Q13564: TM-score 0.99, RMSD 0.61 Å
- 3DBL chain A against the predicted model Q13564: TM-score 0.99, RMSD 0.65 Å
- 3DBL chain A against the predicted model Q13564: TM-score 0.99, RMSD 0.65 Å
- 3DBL chain G against the predicted model Q13564: TM-score 0.99, RMSD 0.66 Å
- 3DBL chain G against the predicted model Q13564: TM-score 0.99, RMSD 0.66 Å
- 3DBH chain G against the predicted model Q13564: TM-score 0.99, RMSD 0.67 Å
- 3DBH chain G against the predicted model Q13564: TM-score 0.99, RMSD 0.67 Å
- 3DBR chain A against the predicted model Q13564: TM-score 0.99, RMSD 0.67 Å
- 3DBR chain A against the predicted model Q13564: TM-score 0.99, RMSD 0.67 Å
Elsewhere
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