UniProt Q15843
NEDD8 (Q15843)
NEDD8 (UniProt Q15843): 44 experimental structures and 1 predicted model on GenesisL1, 15 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q15843
- Protein
- NEDD8
- Experimental structures
- 44
- Predicted models
- 1
- Pockets
- 15 · 4 records with a druggable one
Structures
45 records of Q15843 in the MolNFT archive: 44 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1NDD | Structure of NEDD8 | x-ray diffraction | A, B, C, D | — | — |
| 1NDD | Structure of NEDD8 | x-ray diffraction | A, B, C, D | — | — |
| 1R4M | APPBP1-UBA3-NEDD8, an E1-ubiquitin-like protein complex | x-ray diffraction | I, J, K, L | — | — |
| 1R4M | APPBP1-UBA3-NEDD8, an E1-ubiquitin-like protein complex | x-ray diffraction | I, J, K, L | — | — |
| 1R4N | APPBP1-UBA3-NEDD8, an E1-ubiquitin-like protein complex with ATP | x-ray diffraction | I, J, K, L | — | — |
| 1R4N | APPBP1-UBA3-NEDD8, an E1-ubiquitin-like protein complex with ATP | x-ray diffraction | I, J, K, L | — | — |
| 1XT9 | Crystal Structure of Den1 in complex with Nedd8 | x-ray diffraction | B | — | — |
| 1XT9 | Crystal structure of DEN1 in complex with NEDD8 | x-ray diffraction | B | — | — |
| 2BKR | NEDD8 NEDP1 complex | x-ray diffraction | B | — | — |
| 2BKR | NEDD8 NEDP1 complex | x-ray diffraction | B | — | — |
| 2KO3 | Nedd8 solution structure | solution nmr | A | — | — |
| 2KO3 | NEDD8 solution structure | solution nmr | A | — | — |
| 2N7K | Unveiling the structural determinants of KIAA0323 binding preference for NEDD8 | solution nmr | A | — | — |
| 2N7K | Unveiling the structural determinants of KIAA0323 binding preference for NEDD8 | solution nmr | A | — | — |
| 2NVU | Structure of APPBP1-UBA3~NEDD8-NEDD8-MgATP-Ubc12(C111A), a trapped ubiquitin-like protein… | x-ray diffraction | I, J | — | — |
| 2NVU | Structure of APPBP1-UBA3~NEDD8-NEDD8-mgatp-UBC12(C111A), a trapped ubiquitin-like protein… | x-ray diffraction | I, J | — | — |
| 3DBH | Structural Dissection of a Gating Mechanism Preventing Misactivation of Ubiquitin by NEDD8's E1… | x-ray diffraction | I, J, K, L | — | — |
| 3DBH | Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8'S E1… | x-ray diffraction | I, J, K, L | — | — |
| 3DBL | Structural Dissection of a Gating Mechanism Preventing Misactivation of Ubiquitin by NEDD8's E1… | x-ray diffraction | I, J, K, L | — | — |
| 3DBL | Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8'S E1… | x-ray diffraction | I, J, K, L | — | — |
| 3DBR | Structural Dissection of a Gating Mechanism Preventing Misactivation of Ubiquitin by NEDD8's E1… | x-ray diffraction | I, J, K, L | — | — |
| 3DBR | Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8'S E1… | x-ray diffraction | I, J, K, L | — | — |
| 3DQV | Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of… | x-ray diffraction | A, B | — | — |
| 3DQV | Structural insights into NEDD8 activation of cullin-ring ligases: conformational control of… | x-ray diffraction | A, B | — | — |
| 3GZN | Structure of NEDD8-activating enzyme in complex with NEDD8 and MLN4924 | x-ray diffraction | I, J | — | — |
| 3GZN | Structure of NEDD8-activating enzyme in complex with NEDD8 and MLN4924 | x-ray diffraction | I, J | — | — |
| 4F8C | Structure of the Cif:Nedd8 complex - Yersinia pseudotuberculosis Cycle Inhibiting Factor in complex… | x-ray diffraction | B, D | — | — |
| 4F8C | Structure of the CIF:NEDD8 complex - yersinia pseudotuberculosis cycle inhibiting factor in complex… | x-ray diffraction | B, D | — | — |
| 4FBJ | Structure of the Cif:Nedd8 complex - Photorhabdus luminescens Cycle Inhibiting Factor in complex… | x-ray diffraction | B | — | — |
| 4FBJ | Structure of the CIF:NEDD8 complex - photorhabdus luminescens cycle inhibiting factor in complex… | x-ray diffraction | B | — | — |
| 4HCP | crystal structure of Burkholderia pseudomallei effector protein chbp in complex with nedd8 | x-ray diffraction | B | — | — |
| 4HCP | Crystal structure of burkholderia pseudomallei effector protein chbp in complex with NEDD8 | x-ray diffraction | B | — | — |
| 4P5O | Structure of an RBX1-UBC12~NEDD8-CUL1-DCN1 complex: a RING-E3-E2~ubiquitin-like protein-substrate… | x-ray diffraction | K, H | — | — |
| 4P5O | Structure of an RBX1-UBC12~NEDD8-CUL1-DCN1 complex: a ring-E3- E2~UBIQUITIN-like protein-substrate… | x-ray diffraction | K, H | — | — |
| 6R7F | Structural basis of cullin-2 ring E3 ligase regulation by the COP9 signalosome | electron microscopy | N | — | — |
| 6TTU | Ubiquitin ligation to substrate by a cullin-ring E3 ligase at 3.7A resolution: NEDD8-CUL1-RBX1… | electron microscopy | N | — | — |
| 7B5L | Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly… | electron microscopy | N | — | — |
| 7B5L | Ubiquitin ligation to F-box protein substrates by scf-rbr E3-E3 super- assembly… | electron microscopy | N | — | — |
| 7B5N | Ubiquitin ligation to F-box protein substrates by scf-rbr E3-E3 super- assembly… | electron microscopy | N | — | — |
| 7ONI | Structure of neddylated CUL5 C-terminal region-RBX2-ARIH2* | electron microscopy | N | — | — |
| 8B3I | CRL4CSA-E2-Ub (state 2) | electron microscopy | N | — | 5 (best 0.75) |
| 8Q7H | Structure of CUL9-RBX1 ubiquitin E3 ligase complex in unneddylated and neddylated conformation… | electron microscopy | N | — | 1 (best 0.82) |
| 8RX0 | (NEDD8)-CRL2VHL-MZ1-Brd4BD2-Ub(G76S, K48C)-UBE2R1(C93K, S138C, C191S, C223S)-Ub | electron microscopy | N | — | 3 (best 0.64) |
| 8WQC | cryo-EM structure of neddylated CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CDK5R1 | electron microscopy | N, K | — | 6 (best 0.78) |
| Q15843 | AlphaFold monomer V2.0 prediction for NEDD8 (Q15843) | predicted | A | — | — |
Experiment against prediction
- 1NDD chain A against the predicted model Q15843: TM-score 0.96, RMSD 0.71 Å
- 1NDD chain A against the predicted model Q15843: TM-score 0.96, RMSD 0.71 Å
- 4F8C chain D against the predicted model Q15843: TM-score 0.96, RMSD 0.76 Å
- 4F8C chain D against the predicted model Q15843: TM-score 0.96, RMSD 0.76 Å
- 1NDD chain C against the predicted model Q15843: TM-score 0.95, RMSD 0.77 Å
- 1NDD chain C against the predicted model Q15843: TM-score 0.95, RMSD 0.77 Å
- 8RX0 chain N against the predicted model Q15843: TM-score 0.95, RMSD 0.62 Å
- 4FBJ chain B against the predicted model Q15843: TM-score 0.94, RMSD 1.21 Å
- 4FBJ chain B against the predicted model Q15843: TM-score 0.94, RMSD 1.21 Å
- 1XT9 chain B against the predicted model Q15843: TM-score 0.94, RMSD 0.88 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.