Research workbench
SAC3:SUS1:CDC31 complex
Analyse SAC3:SUS1:CDC31 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3FWB
- Type
- protein
- Length
- 297 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cell division control protein 31; Nuclear mRNA export protein SAC3; Protein SUS1
- UniProt
- P06704, P46674, Q6WNK7
- Pockets
- 3 · best druggability 0.61
Structure
x-ray diffraction · 3 distinct chains · 71% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cell division control protein 31 | protein | 153 | 58% helix, 5% strand | P06704 |
| B | Nuclear mRNA export protein SAC3 | protein | 54 | 94% helix, 0% strand | P46674 |
| C | Protein SUS1 | protein | 90 | 78% helix, 0% strand | Q6WNK7 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 422 | 0.61 | 0.76 | 47 | empty |
| 2 | 90 | 0.35 | 0.75 | 18 | empty |
| 3 | 69 | 0.34 | 0.76 | 13 | empty |
Interfaces
3 interfaces between chains.
- B–C · 1647 Ų buried · 15 hydrogen bonds · protein-protein
- A–B · 1515 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 153 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3FWB · Sac3:Sus1:Cdc31 complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q6WNK7 · AlphaFold monomer V2.0 prediction for transcription and mRNA export factor SUS1 (Q6WNK7) · a predicted model of the same protein · chain C against A, TM-score 0.90
- P46674 · AlphaFold monomer V2.0 prediction for nuclear mRNA export protein SAC3 (P46674) · a predicted model of the same protein · chain B against A, TM-score 0.84
- P06704 · AlphaFold monomer V2.0 prediction for cell division control protein 31 (P06704) · a predicted model of the same protein · chain A against A, TM-score 0.83
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06704
- Every structure of UniProt P46674
- Every structure of UniProt Q6WNK7
- Elsewhere: RCSB PDB 3FWB · PDBe 3FWB · UniProt P06704 · UniProt P46674 · UniProt Q6WNK7
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