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Crystal structure of monomeric actin bound to ca-ATP

Analyse Crystal structure of monomeric actin bound to ca-ATP in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3EL2
Type: protein
Length: 362 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Actin-5C
UniProt: P10987
Ligands: ATP, CA
Pockets: 2 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Actin-5C	protein	362	43% helix, 20% strand	P10987

Ligands and binding sites

ATP · Adenosine-5'-triphosphate · ligand · chains A
CA · Calcium ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	494	0.75	0.84	54	ATP, CA
2	169	0.53	0.78	24	empty

Compared structures

3EL2 · Crystal Structure of Monomeric Actin Bound to Ca-ATP · the same entry in another collection · chain A against A, TM-score 1.00
P10987 · AlphaFold monomer V2.0 prediction for actin-5C (P10987) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10987
Elsewhere: RCSB PDB 3EL2 · PDBe 3EL2 · UniProt P10987

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