Research workbench
Crystal structure of the extracellular domain of human corticotropin releasing factor receptor type 1 (CRFR1) in complex with crf
Analyse Crystal structure of the extracellular domain of human corticotropin releasing… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3EHT
- Type
- protein
- Length
- 463 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fusion protein of CRFR1 extracellular domain and mbp; Corticoliberin
- UniProt
- P0AEX9, P34998, P06850
- Ligands
- GLC, NH2
- Pockets
- 3 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fusion protein of CRFR1 extracellular domain and mbp | protein | 452 | 37% helix, 25% strand | P0AEX9, P34998 |
| B | Corticoliberin | protein | 11 | 82% helix, 0% strand | P06850 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 318 | 0.71 | 0.84 | 34 | GLC |
| 2 | 151 | 0.41 | 0.74 | 27 | empty |
| 3 | 53 | 0.41 | 0.82 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 407 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 3EHT · Crystal structure of the extracellular domain of human corticotropin releasing factor… · the same entry in another collection · chain A against A, TM-score 1.00
- P06850 · AlphaFold monomer V2.0 prediction for corticoliberin (P06850) · a predicted model of the same protein · chain B against A, TM-score 0.71
- P34998 · AlphaFold monomer V2.0 prediction for corticotropin-releasing factor receptor 1 (P34998) · a predicted model of the same protein · chain A against A, TM-score 0.24
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AEX9
- Every structure of UniProt P34998
- Every structure of UniProt P06850
- Elsewhere: RCSB PDB 3EHT · PDBe 3EHT · UniProt P0AEX9 · UniProt P34998 · UniProt P06850
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