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E(L212)A, D(L213)A, R(M233)L triple mutant structure of photosynthetic reaction center from rhodobacter sphaeroides
Analyse E(L212)A, D(L213)A, R(M233)L triple mutant structure of photosynthetic reaction… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3DTS
- Type
- protein
- Length
- 823 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Reaction center protein L chain; Reaction center protein M chain; Reaction center protein…
- UniProt
- P0C0Y8, P0C0Y9, P0C0Y7
- Ligands
- BCL, U10, BPH, SPN, CDL, FE
- Pockets
- 18 · best druggability 0.82
Structure
x-ray diffraction · 3 distinct chains · 50% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | Reaction center protein L chain | protein | 281 | 61% helix, 4% strand | P0C0Y8 |
| M | Reaction center protein M chain | protein | 302 | 61% helix, 4% strand | P0C0Y9 |
| H | Reaction center protein H chain | protein | 240 | 23% helix, 23% strand | P0C0Y7 |
Ligands and binding sites
- BCL · Bacteriochlorophyll A · ligand · 4 copies · chains L, M
- U10 · Ubiquinone-10 · ligand · 2 copies · chains L, M
- BPH · Bacteriopheophytin A · ligand · 2 copies · chains L, M
- SPN · Speroidenone · ligand · chains M
- CDL · Cardiolipin · ligand · chains L, M, H
- FE · Fe (III) ion · metal · chains L, M
- LDA · Lauryl dimethylamine-N-oxide · additive · 4 copies · chains L, M, H
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
18 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1169 | 0.82 | 0.82 | 83 | BCL, SPN |
| 2 | 112 | 0.78 | 0.97 | 32 | empty |
| 3 | 68 | 0.71 | 0.97 | 19 | empty |
| 4 | 158 | 0.69 | 0.88 | 21 | U10 |
| 5 | 171 | 0.68 | 0.87 | 28 | U10 |
Interfaces
3 interfaces between chains.
- L–M · 4663 Ų buried · 68 hydrogen bonds · protein-protein
- M–H · 2833 Ų buried · 33 hydrogen bonds · protein-protein
- L–H · 1624 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 3DTS · E(L212)A, D(L213)A, R(M233)L triple mutant structure of photosynthetic reaction center… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0C0Y8
- Every structure of UniProt P0C0Y9
- Every structure of UniProt P0C0Y7
- Elsewhere: RCSB PDB 3DTS · PDBe 3DTS · UniProt P0C0Y8 · UniProt P0C0Y9 · UniProt P0C0Y7
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