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Crystal structure of P. furiosus MRE11 DNA synaptic complex

Analyse Crystal structure of P. furiosus MRE11 DNA synaptic complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3DSC
Type: protein + DNA
Length: 350 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA double-strand break repair protein MRE11; DNA (5'…
UniProt: Q8U1N9
Pockets: 2 · best druggability 0.47

Structure

x-ray diffraction · 2 distinct chains · 24% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA double-strand break repair protein MRE11	protein	333	24% helix, 31% strand	Q8U1N9
B	DNA (5'- D(PDCPDAPDCPDAPDAPDGPDCPDTPDTPDTPDTPDGPDCPDTPDTPDGPD TPDGPDAPDC)-3')	dna	17	—	—

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	129	0.47	0.79	21	empty
2	75	0.29	0.74	11	empty

Interfaces

1 interface between chains.

A–B · 524 Å² buried · 9 hydrogen bonds · protein-nucleic

Compared structures

3DSC · Crystal structure of P. furiosus Mre11 DNA synaptic complex · the same entry in another collection · chain A against A, TM-score 1.00
Q8U1N9 · AlphaFold monomer V2.0 prediction for DNA double-strand break repair protein MRE11… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8U1N9
Elsewhere: RCSB PDB 3DSC · PDBe 3DSC · UniProt Q8U1N9

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