MolNFT v1 · #243953 · protein
AlphaFold monomer V2.0 prediction for DNA double-strand break repair protein MRE11 (Q8U1N9)
Q8U1N9: “AlphaFold monomer V2.0 prediction for DNA double-strand break repair protein MRE11 (Q8U1N9)”. 3 pockets (best druggability 0.44). MolNFT v1 #243953 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q8U1N9
- Type
- protein
- Length
- 426 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xf87a97E0A4bB354D834857B14296240B167cbe70
- Molecule
- DNA double-strand break repair protein MRE11
- UniProt
- Q8U1N9
- Pockets
- 3 · best druggability 0.44
Structure
1 distinct chain · 30% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA double-strand break repair protein MRE11 | protein | 426 | 30% helix, 25% strand | Q8U1N9 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 147 | 0.44 | 0.76 | 21 | empty |
| 2 | 103 | 0.40 | 0.76 | 17 | empty |
| 3 | 93 | 0.38 | 0.75 | 23 | empty |
Compared structures
- 3DSD · Crystal structure of P. furiosus MRE11-H85S bound to a branched DNA and manganese · an experimental structure of the same protein · chain A against A, TM-score 0.78
- 3DSD · Crystal structure of P. furiosus Mre11-H85S bound to a branched DNA and manganese · an experimental structure of the same protein · chain A against A, TM-score 0.78
- 1II7 · Crystal structure of P. furiosus MRE11 with manganese and damp · an experimental structure of the same protein · chain A against A, TM-score 0.78
- 1II7 · Crystal structure of P. furiosus Mre11 with manganese and dAMP · an experimental structure of the same protein · chain A against A, TM-score 0.78
- 1S8E · Crystal structure of MRE11-3 · an experimental structure of the same protein · chain A against A, TM-score 0.78
- 1S8E · Crystal structure of Mre11-3 · an experimental structure of the same protein · chain A against A, TM-score 0.78
- 3DSC · Crystal structure of P. furiosus Mre11 DNA synaptic complex · an experimental structure of the same protein · chain A against A, TM-score 0.77
- 3DSC · Crystal structure of P. furiosus MRE11 DNA synaptic complex · an experimental structure of the same protein · chain A against A, TM-score 0.77
- 4HD0 · MRE11 ATLD17/18 mutation retains TEL1/ATM activity but blocks DNA double-strand break… · an experimental structure of the same protein · chain A against A, TM-score 0.77
- 4HD0 · Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break… · an experimental structure of the same protein · chain A against A, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8U1N9
- Elsewhere: UniProt Q8U1N9 · AlphaFold DB Q8U1N9
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