UniProt Q8U1N9
Mre11 nuclease (Q8U1N9)
Mre11 nuclease (UniProt Q8U1N9): 16 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 9 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8U1N9
- Protein
- Mre11 nuclease
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 9 · 0 records with a druggable one
Structures
17 records of Q8U1N9 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1II7 | Crystal structure of P. furiosus Mre11 with manganese and dAMP | x-ray diffraction | A, B | MN, SO4, D5M, PO4 | 6 (best 0.49) |
| 1II7 | Crystal structure of P. furiosus MRE11 with manganese and damp | x-ray diffraction | A, B | — | — |
| 1S8E | Crystal structure of Mre11-3 | x-ray diffraction | A, B | — | — |
| 1S8E | Crystal structure of MRE11-3 | x-ray diffraction | A, B | — | — |
| 3DSC | Crystal structure of P. furiosus Mre11 DNA synaptic complex | x-ray diffraction | A | — | — |
| 3DSC | Crystal structure of P. furiosus MRE11 DNA synaptic complex | x-ray diffraction | A | — | — |
| 3DSD | Crystal structure of P. furiosus Mre11-H85S bound to a branched DNA and manganese | x-ray diffraction | A, B | — | — |
| 3DSD | Crystal structure of P. furiosus MRE11-H85S bound to a branched DNA and manganese | x-ray diffraction | A, B | — | — |
| 3QKR | Mre11 Rad50 binding domain bound to Rad50 | x-ray diffraction | C | — | — |
| 3QKR | MRE11 RAD50 binding domain bound to RAD50 | x-ray diffraction | C | — | — |
| 3QKS | Mre11 Rad50 binding domain bound to Rad50 | x-ray diffraction | C | — | — |
| 3QKS | MRE11 RAD50 binding domain bound to RAD50 | x-ray diffraction | C | — | — |
| 3QKU | Mre11 Rad50 binding domain in complex with Rad50 and AMP-PNP | x-ray diffraction | C | — | — |
| 3QKU | MRE11 RAD50 binding domain in complex with RAD50 and AMP-pnp | x-ray diffraction | C | — | — |
| 4HD0 | Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair | x-ray diffraction | A, B | — | — |
| 4HD0 | MRE11 ATLD17/18 mutation retains TEL1/ATM activity but blocks DNA double-strand break repair | x-ray diffraction | A, B | — | — |
| Q8U1N9 | AlphaFold monomer V2.0 prediction for DNA double-strand break repair protein MRE11 (Q8U1N9) | predicted | A | — | 3 (best 0.44) |
Ligands
Experiment against prediction
- 3DSD chain A against the predicted model Q8U1N9: TM-score 1.00, RMSD 0.40 Å
- 3DSD chain A against the predicted model Q8U1N9: TM-score 1.00, RMSD 0.40 Å
- 1II7 chain A against the predicted model Q8U1N9: TM-score 1.00, RMSD 0.41 Å
- 1II7 chain A against the predicted model Q8U1N9: TM-score 1.00, RMSD 0.41 Å
- 1II7 chain B against the predicted model Q8U1N9: TM-score 1.00, RMSD 0.43 Å
- 1II7 chain B against the predicted model Q8U1N9: TM-score 1.00, RMSD 0.43 Å
- 1S8E chain A against the predicted model Q8U1N9: TM-score 1.00, RMSD 0.47 Å
- 1S8E chain A against the predicted model Q8U1N9: TM-score 1.00, RMSD 0.47 Å
- 3DSC chain A against the predicted model Q8U1N9: TM-score 0.99, RMSD 0.71 Å
- 3DSC chain A against the predicted model Q8U1N9: TM-score 0.99, RMSD 0.71 Å
Elsewhere
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