Research workbench
Nucleoporin NUP107/NUP133 interaction complex
Analyse Nucleoporin NUP107/NUP133 interaction complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3CQC
- Type
- protein
- Length
- 433 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nuclear pore complex protein NUP107; Nuclear pore complex protein NUP133
- UniProt
- P57740, Q8WUM0
- Pockets
- 5 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 68% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nuclear pore complex protein NUP107 | protein | 247 | 73% helix, 1% strand | P57740 |
| B | Nuclear pore complex protein NUP133 | protein | 186 | 62% helix, 0% strand | Q8WUM0 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 361 | 0.64 | 0.79 | 38 | empty |
| 2 | 138 | 0.46 | 0.77 | 25 | empty |
| 3 | 61 | 0.43 | 0.82 | 13 | empty |
| 4 | 71 | 0.38 | 0.78 | 17 | empty |
| 5 | 59 | 0.36 | 0.79 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1233 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 3CQC · Nucleoporin Nup107/Nup133 interaction complex · the same entry in another collection · chain A against A, TM-score 1.00
- P57740 · AlphaFold monomer V2.0 prediction for nuclear pore complex protein NUP107 (P57740) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q8WUM0 · AlphaFold monomer V2.0 prediction for nuclear pore complex protein NUP133 (Q8WUM0) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P57740
- Every structure of UniProt Q8WUM0
- Elsewhere: RCSB PDB 3CQC · PDBe 3CQC · UniProt P57740 · UniProt Q8WUM0
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