Research workbench
Complex of dictyostelium discoideum actin with gelsolin
Analyse Complex of dictyostelium discoideum actin with gelsolin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3CIP
- Type
- protein
- Length
- 491 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Major actin; Gelsolin
- UniProt
- P07830, P06396
- Ligands
- ATP, MG, CA, SO4
- Pockets
- 4 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Major actin | protein | 363 | 45% helix, 20% strand | P07830 |
| G | Gelsolin | protein | 128 | 23% helix, 34% strand | P06396 |
Ligands and binding sites
- ATP · Adenosine-5'-triphosphate · ligand · chains A
- MG · Magnesium ion · metal · chains A
- CA · Calcium ion · metal · chains G
- SO4 · Sulfate ion · ion · 9 copies · chains A, G
- GOL · Glycerol · additive · 3 copies · chains A, G
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 466 | 0.73 | 0.82 | 49 | MG, SO4, ATP |
| 2 | 279 | 0.68 | 0.83 | 40 | empty |
| 3 | 184 | 0.48 | 0.76 | 21 | empty |
| 4 | 70 | 0.29 | 0.73 | 18 | empty |
Interfaces
1 interface between chains.
- A–G · 1311 Ų buried · 23 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (methylation).
Compared structures
- 3CIP · Complex of Dictyostelium Discoideum Actin with Gelsolin · the same entry in another collection · chain A against A, TM-score 1.00
- P07830 · AlphaFold monomer V2.0 prediction for major actin (P07830) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P06396 · AlphaFold monomer V2.0 prediction for gelsolin (P06396) · a predicted model of the same protein · chain G against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07830
- Every structure of UniProt P06396
- Elsewhere: RCSB PDB 3CIP · PDBe 3CIP · UniProt P07830 · UniProt P06396
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