Research workbench
X-ray structure of the C-terminal ULP1 protease domain in complex with SMT3, the yeast ortholog of sumo.
Analyse X-ray structure of the C-terminal ULP1 protease domain in complex with SMT3… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1EUV
- Type
- protein
- Length
- 300 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ULP1 protease; Ubitqutin-like protein SMT3
- UniProt
- Q02724, Q12306
- Pockets
- 4 · best druggability 0.57
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ULP1 protease | protein | 221 | 43% helix, 18% strand | Q02724 |
| B | Ubitqutin-like protein SMT3 | protein | 79 | 16% helix, 37% strand | Q12306 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 142 | 0.57 | 0.83 | 18 | empty |
| 2 | 176 | 0.47 | 0.76 | 36 | empty |
| 3 | 102 | 0.45 | 0.79 | 24 | empty |
| 4 | 83 | 0.38 | 0.77 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1222 Ų buried · 43 hydrogen bonds · protein-protein
Compared structures
- 1EUV · X-ray structure of the C-terminal ULP1 protease domain in complex with SMT3, the yeast… · the same entry in another collection · chain A against A, TM-score 1.00
- Q02724 · AlphaFold monomer V2.0 prediction for ubiquitin-like-specific protease 1 (Q02724) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q12306 · AlphaFold monomer V2.0 prediction for ubiquitin-like protein SMT3 (Q12306) · a predicted model of the same protein · chain B against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q02724
- Every structure of UniProt Q12306
- Elsewhere: RCSB PDB 1EUV · PDBe 1EUV · UniProt Q02724 · UniProt Q12306
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