Research workbench
Crystal structure of the ternary complex of EIF4E-M7GTP-4EBP2 peptide
Analyse Crystal structure of the ternary complex of EIF4E-M7GTP-4EBP2 peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3AM7
- Type
- protein
- Length
- 209 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 4E; Eukaryotic translation initiation factor…
- UniProt
- P06730, Q13542
- Ligands
- MGP
- Pockets
- 1 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 29% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic translation initiation factor 4E | protein | 190 | 29% helix, 27% strand | P06730 |
| B | Eukaryotic translation initiation factor 4E-binding protein 2 | protein | 19 | 26% helix, 0% strand | Q13542 |
Ligands and binding sites
- MGP · 7-methyl-guanosine-5'-triphosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 229 | 0.58 | 0.79 | 30 | MGP |
Interfaces
1 interface between chains.
- A–B · 786 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 3AM7 · Crystal structure of the ternary complex of eIF4E-M7GTP-4EBP2 peptide · the same entry in another collection · chain A against A, TM-score 1.00
- P06730 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E (P06730) · a predicted model of the same protein · chain A against A, TM-score 0.95
- Q13542 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E-binding… · a predicted model of the same protein · chain B against A, TM-score 0.37
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06730
- Every structure of UniProt Q13542
- Elsewhere: RCSB PDB 3AM7 · PDBe 3AM7 · UniProt P06730 · UniProt Q13542
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