Research workbench
Insight into E-SELECTIN(SLASH)LIGAND interaction from the crystal structure and mutagenesis of the LEC(SLASH)EGF domains
Analyse Insight into E-SELECTIN(SLASH)LIGAND interaction from the crystal structure and… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ESL
- Type
- protein
- Length
- 157 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Human E-selectin
- UniProt
- P16581
- Ligands
- CA, CL
- Pockets
- 1 · best druggability 0.34
Structure
x-ray diffraction · 1 distinct chain · 15% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Human E-selectin | protein | 157 | 15% helix, 32% strand | P16581 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 68 | 0.34 | 0.76 | 19 | empty |
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 1ESL · Insight into E-SELECTIN(SLASH)LIGAND interaction from the crystal structure and… · the same entry in another collection · chain A against A, TM-score 1.00
- P16581 · AlphaFold monomer V2.0 prediction for E-selectin (P16581) · a predicted model of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P16581
- Elsewhere: RCSB PDB 1ESL · PDBe 1ESL · UniProt P16581
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