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Rhamnose-binding lectin CSL3

Analyse Rhamnose-binding lectin CSL3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2ZX4
Type: protein
Length: 390 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CSL3
Ligands: GAL, GLA, BGC, PO4
Pockets: 3 · best druggability 0.59

Structure

x-ray diffraction · 1 distinct chain · 16% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	CSL3	protein	195	16% helix, 34% strand	—

Ligands and binding sites

GAL · beta-D-galactopyranose · sugar · 4 copies · chains A, B
GLA · alpha-D-galactopyranose · sugar · 4 copies · chains A, B
BGC · beta-D-glucopyranose · sugar · 2 copies · chains A
PO4 · Phosphate ion · ion · 2 copies · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	212	0.59	0.80	37	PO4
2	233	0.58	0.79	37	empty
3	317	0.55	0.75	59	empty

Interfaces

1 interface between chains.

A–B · 1602 Å² buried · 32 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 16 disulfide (disulfide).

Compared structures

2ZX4 · Rhamnose-binding lectin CSL3 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 2ZX4 · PDBe 2ZX4

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