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Crystal structure of a platinum-bound S445C mutant of pseudomonas sp. MIS38 lipase

Analyse Crystal structure of a platinum-bound S445C mutant of pseudomonas sp. MIS38… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2Z8Z
Type: protein
Length: 616 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lipase
EC: 3.1.1.3
UniProt: Q9RBY1
Ligands: CA, ZN, PT
Pockets: 5 · best druggability 0.62

Structure

x-ray diffraction · 1 distinct chain · 26% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Lipase (EC 3.1.1.3)	protein	616	26% helix, 27% strand	Q9RBY1

Ligands and binding sites

CA · Calcium ion · metal · 11 copies · chains A
ZN · Zinc ion · metal · 2 copies · chains A
PT · Platinum (II) ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	291	0.62	0.80	48	empty
2	58	0.61	0.92	18	empty
3	58	0.54	0.88	18	PT
4	180	0.52	0.78	33	empty
5	62	0.44	0.83	28	empty

Compared structures

2Z8Z · Crystal structure of a platinum-bound S445C mutant of Pseudomonas sp. MIS38 lipase · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9RBY1
Elsewhere: RCSB PDB 2Z8Z · PDBe 2Z8Z · UniProt Q9RBY1

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