Research workbench
Complex of transportin 1 with tap nls
Analyse Complex of transportin 1 with tap nls in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2Z5K
- Type
- protein
- Length
- 852 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transportin-1; Nuclear RNA export factor 1
- UniProt
- Q92973, Q9UBU9
- Ligands
- PO4
- Pockets
- 8 · best druggability 0.52
Structure
x-ray diffraction · 2 distinct chains · 75% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transportin-1 | protein | 840 | 77% helix, 0% strand | Q92973 |
| B | Nuclear RNA export factor 1 | protein | 12 | 0% helix, 0% strand | Q9UBU9 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 132 | 0.52 | 0.81 | 21 | empty |
| 2 | 265 | 0.46 | 0.72 | 34 | empty |
| 3 | 131 | 0.39 | 0.74 | 22 | empty |
| 4 | 61 | 0.39 | 0.80 | 14 | empty |
| 5 | 69 | 0.39 | 0.78 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 736 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 2Z5K · Complex of Transportin 1 with TAP NLS · the same entry in another collection · chain A against A, TM-score 1.00
- Q92973 · AlphaFold monomer V2.0 prediction for transportin-1 (Q92973) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q9UBU9 · AlphaFold monomer V2.0 prediction for nuclear RNA export factor 1 (Q9UBU9) · a predicted model of the same protein · chain B against A, TM-score 0.29
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92973
- Every structure of UniProt Q9UBU9
- Elsewhere: RCSB PDB 2Z5K · PDBe 2Z5K · UniProt Q92973 · UniProt Q9UBU9
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