L38V SOD1 mutant complexed with aniline.

Structure

x-ray diffraction · 1 distinct chain · 7% helix, 41% strand (DSSP).

Ligands and binding sites

• ZZT · 2-methoxy-5-methylaniline · ligand · 2 copies · chains A, F
• DSN · D-serine · ligand · chains F
• ZN · Zinc ion · metal · 3 copies · chains A, F
• CU · Copper (II) ion · metal · 2 copies · chains A, F
• SO4 · Sulfate ion · ion · 2 copies · chains A, F
• DMS · Dimethyl sulfoxide · additive · chains F

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–F · 713 Ų buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

• 2WZ0 · L38V SOD1 mutant complexed with aniline. · the same entry in another collection · chain A against A, TM-score 1.00
• P00441 · AlphaFold monomer V2.0 prediction for superoxide dismutase [cu-zn] (P00441) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P00441
• Elsewhere: RCSB PDB 2WZ0 · PDBe 2WZ0 · UniProt P00441