Research workbench
Crystal structure of yeast karyopherin (importin) alpha in a complex with a C-myc nls peptide
Analyse Crystal structure of yeast karyopherin (importin) alpha in a complex with a… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1EE4
- Type
- protein
- Length
- 873 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Karyopherin alpha; Myc proto-oncogene protein
- UniProt
- Q02821, P01106
- Pockets
- 2 · best druggability 0.29
Structure
x-ray diffraction · 4 distinct chains · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Karyopherin alpha | protein | 423 | 74% helix, 0% strand | Q02821 |
| C, E | Myc proto-oncogene protein | protein | 9 | 0% helix, 0% strand | P01106 |
| D | Myc proto-oncogene protein | protein | 5 | 0% helix, 0% strand | P01106 |
| F | Myc proto-oncogene protein | protein | 4 | 0% helix, 0% strand | P01106 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 53 | 0.29 | 0.76 | 13 | empty |
| 2 | 53 | 0.26 | 0.73 | 17 | empty |
Interfaces
4 interfaces between chains.
- A–C · 734 Ų buried · 18 hydrogen bonds · protein-protein
- B–E · 711 Ų buried · 17 hydrogen bonds · protein-protein
- A–D · 411 Ų buried · 12 hydrogen bonds · protein-protein
- B–F · 374 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 1EE4 · Crystal structure of yeast karyopherin (importin) alpha in a complex with a C-myc nls… · the same entry in another collection · chain F against F, TM-score 1.00
- Q02821 · AlphaFold monomer V2.0 prediction for importin subunit alpha (Q02821) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P01106 · AlphaFold monomer V2.0 prediction for myc proto-oncogene protein (P01106) · a predicted model of the same protein · chain F against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q02821
- Every structure of UniProt P01106
- Elsewhere: RCSB PDB 1EE4 · PDBe 1EE4 · UniProt Q02821 · UniProt P01106
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