UniProt P01106
Myc proto-oncogene protein (P01106)
Myc proto-oncogene protein (UniProt P01106), EC 2.3.1.48: 30 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 22 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P01106
- Protein
- Myc proto-oncogene protein
- EC
- 2.3.1.48
- Experimental structures
- 30
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 22 · 6 records with a druggable one
Structures
31 records of P01106 in the MolNFT archive: 30 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A93 | NMR solution structure of the C-myc-max heterodimeric leucine zipper, NMR, minimized average… | solution nmr | A | — | — |
| 1A93 | NMR solution structure of the C-myc-max heterodimeric leucine zipper, NMR, minimized average… | solution nmr | A | — | — |
| 1EE4 | Crystal structure of yeast karyopherin (importin) alpha in a complex with a C-myc nls peptide | x-ray diffraction | C, D, E, F | — | — |
| 1EE4 | Crystal structure of yeast karyopherin (importin) alpha in a complex with a C-myc nls peptide | x-ray diffraction | C, D, E, F | — | — |
| 1MV0 | NMR structure of the tumor suppressor BIN1: alternative splicing in melanoma and interaction with… | solution nmr | A | — | — |
| 1MV0 | NMR structure of the tumor suppressor BIN1: alternative splicing in melanoma and interaction with… | solution nmr | A | — | — |
| 1NKP | Crystal structure of Myc-Max recognizing DNA | x-ray diffraction | A, D | — | — |
| 1NKP | Crystal structure of myc-max recognizing DNA | x-ray diffraction | A, D | — | — |
| 2A93 | NMR solution structure of the C-myc-max heterodimeric leucine zipper, 40 structures | solution nmr | A | — | — |
| 2A93 | NMR solution structure of the C-myc-max heterodimeric leucine zipper, 40 structures | solution nmr | A | — | — |
| 5I4Z | Structure of apo OmoMYC | x-ray diffraction | A, B | CL, K | — |
| 5I4Z | Structure of apo omomyc | x-ray diffraction | A, B | — | — |
| 5I50 | Structure of OmoMYC bound to double-stranded DNA | x-ray diffraction | A, B | — | — |
| 5I50 | Structure of omomyc bound to double-stranded DNA | x-ray diffraction | A, B | — | — |
| 6E16 | Ternary structure of c-Myc-TBP-TAF1 | x-ray diffraction | A | — | 1 (best 0.49) |
| 6E16 | Ternary structure of C-myc-tbp-TAF1 | x-ray diffraction | A | — | — |
| 6E24 | Ternary structure of c-Myc-TBP-TAF1 | x-ray diffraction | A | — | 2 (best 0.46) |
| 6E24 | Ternary structure of C-myc-tbp-TAF1 | x-ray diffraction | A | — | — |
| 6G6J | The crystal structures of Human MYC:MAX bHLHZip complex | x-ray diffraction | A, C | SO4 | 1 (best 0.37) |
| 6G6J | The crystal structures of human MYC:MAX bhlhzip complex | x-ray diffraction | A, C | SO4 | — |
| 6G6K | The crystal structures of Human MYC:MAX bHLHZip complex | x-ray diffraction | A, C | CL | 1 (best 0.63) |
| 6G6K | The crystal structures of human MYC:MAX bhlhzip complex | x-ray diffraction | A, C | CL | — |
| 6G6L | The crystal structures of Human MYC:MAX bHLHZip complex | x-ray diffraction | A, C, E, G | SO4 | 8 (best 0.38) |
| 6G6L | The crystal structures of human MYC:MAX bhlhzip complex | x-ray diffraction | A, C, E, G | SO4 | — |
| 8J2Q | Crystal structure of Cypovirus Polyhedra mutant fused with c-Myc fragment | x-ray diffraction | A | — | 2 (best 0.54) |
| 8OTS | OCT4 and MYC-MAX co-bound to a nucleosome | electron microscopy | M | — | 2 (best 0.76) |
| 8OTT | MYC-MAX bound to a nucleosome at SHL+5.8 | electron microscopy | M | — | 2 (best 0.76) |
| 8WLG | Crystal structure of Cypovirus Polyhedra mutant fused with c-Myc fragment | x-ray diffraction | A | — | 1 (best 0.51) |
| 8X8S | Crystal structure of Cypovirus Polyhedra mutant fused with c-Myc fragment | x-ray diffraction | A | — | 1 (best 0.46) |
| 8X8V | Crystal structure of Cypovirus Polyhedra mutant fused with c-Myc fragment | x-ray diffraction | A | — | 1 (best 0.52) |
| P01106 | AlphaFold monomer V2.0 prediction for myc proto-oncogene protein (P01106) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6G6L chain C against the predicted model P01106: TM-score 0.96, RMSD 0.66 Å
- 6G6L chain C against the predicted model P01106: TM-score 0.96, RMSD 0.66 Å
- 8OTS chain M against the predicted model P01106: TM-score 0.96, RMSD 0.67 Å
- 6G6J chain C against the predicted model P01106: TM-score 0.96, RMSD 0.71 Å
- 6G6J chain C against the predicted model P01106: TM-score 0.96, RMSD 0.71 Å
- 8OTT chain M against the predicted model P01106: TM-score 0.96, RMSD 0.52 Å
- 6G6J chain A against the predicted model P01106: TM-score 0.96, RMSD 0.73 Å
- 6G6J chain A against the predicted model P01106: TM-score 0.96, RMSD 0.73 Å
- 6G6L chain A against the predicted model P01106: TM-score 0.95, RMSD 0.73 Å
- 6G6L chain A against the predicted model P01106: TM-score 0.95, RMSD 0.73 Å
Elsewhere
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