Research workbench
Isometrically contracting insect asynchronous flight muscle quick frozen after a quick release step
Analyse Isometrically contracting insect asynchronous flight muscle quick frozen after… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2W4V
- Type
- protein
- Length
- 1,059 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin heavy chain, striated muscle; Myosin regulatory light chain, striated adductor…
- UniProt
- P24733, P13543, P07291
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 3 distinct chains · 49% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Myosin heavy chain, striated muscle | protein | 772 | 48% helix, 14% strand | P24733 |
| Y | Myosin regulatory light chain, striated adductor muscle | protein | 136 | 54% helix, 4% strand | P13543 |
| Z | Myosin essential light chain, striated adductor muscle | protein | 151 | 54% helix, 4% strand | P07291 |
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 718 | 0.83 | 0.87 | 92 | empty |
| 2 | 166 | 0.79 | 0.94 | 35 | empty |
| 3 | 160 | 0.77 | 0.93 | 26 | empty |
| 4 | 141 | 0.73 | 0.92 | 33 | empty |
| 5 | 177 | 0.73 | 0.90 | 36 | empty |
Interfaces
3 interfaces between chains.
- C–Z · 1624 Ų buried · 20 hydrogen bonds · protein-protein
- C–Y · 1570 Ų buried · 9 hydrogen bonds · protein-protein
- Y–Z · 330 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 isopeptide (isopeptide).
Compared structures
- 2W4V · Isometrically contracting insect asynchronous flight muscle quick frozen after a quick… · the same entry in another collection · chain C against C, TM-score 1.00
- P07291 · AlphaFold monomer V2.0 prediction for myosin essential light chain, striated adductor… · a predicted model of the same protein · chain Z against A, TM-score 0.98
- P13543 · AlphaFold monomer V2.0 prediction for myosin regulatory light chain, striated adductor… · a predicted model of the same protein · chain Y against A, TM-score 0.89
- P24733 · AlphaFold monomer V2.0 prediction for myosin heavy chain, striated muscle (P24733) · a predicted model of the same protein · chain C against A, TM-score 0.84
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P24733
- Every structure of UniProt P13543
- Every structure of UniProt P07291
- Elsewhere: RCSB PDB 2W4V · PDBe 2W4V · UniProt P24733 · UniProt P13543 · UniProt P07291
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