Decoding of methylated histone H3 tail by the pygo-BCL9 wnt signaling complex

Structure

x-ray diffraction · 2 distinct chains · 26% helix, 15% strand (DSSP).

Ligands and binding sites

• ZN · Zinc ion · metal · 2 copies · chains A
• SO4 · Sulfate ion · ion · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 672 Ų buried · 9 hydrogen bonds · protein-protein

Compared structures

• 2VP7 · Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex · the same entry in another collection · chain A against A, TM-score 1.00
• Q9Y3Y4 · AlphaFold monomer V2.0 prediction for pygopus homolog 1 (Q9Y3Y4) · a predicted model of the same protein · chain A against A, TM-score 0.86
• O00512 · AlphaFold monomer V2.0 prediction for B-cell CLL/LYMPHOMA 9 protein (O00512) · a predicted model of the same protein · chain B against A, TM-score 0.70

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9Y3Y4
• Every structure of UniProt O00512
• Elsewhere: RCSB PDB 2VP7 · PDBe 2VP7 · UniProt Q9Y3Y4 · UniProt O00512