Research workbench
Crystal structure of human reticulon 4 interacting protein 1 in complex with NADPH
Analyse Crystal structure of human reticulon 4 interacting protein 1 in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2VN8
- Type
- protein
- Length
- 713 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Reticulon-4-interacting protein 1
- UniProt
- Q8WWV3
- Ligands
- NDP, NA
- Pockets
- 3 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Reticulon-4-interacting protein 1 | protein | 358 | 36% helix, 24% strand | Q8WWV3 |
| B | Reticulon-4-interacting protein 1 | protein | 355 | 37% helix, 25% strand | Q8WWV3 |
Ligands and binding sites
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · ligand · 2 copies · chains A, B
- NA · Sodium ion · metal · chains A
- CIT · Citric acid · additive · chains A
- GOL · Glycerol · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 732 | 0.74 | 0.79 | 68 | NDP |
| 2 | 755 | 0.73 | 0.78 | 61 | NDP |
| 3 | 731 | 0.68 | 0.76 | 80 | empty |
Interfaces
1 interface between chains.
- A–B · 637 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 2VN8 · Crystal structure of human Reticulon 4 interacting protein 1 in complex with NADPH · the same entry in another collection · chain A against A, TM-score 1.00
- Q8WWV3 · AlphaFold monomer V2.0 prediction for reticulon-4-interacting protein 1, mitochondrial… · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8WWV3
- Elsewhere: RCSB PDB 2VN8 · PDBe 2VN8 · UniProt Q8WWV3
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