Research workbench
The crystal structure of the human G-protein subunit alpha (GNAI3) in complex with an engineered regulator of G-protein signaling type 2 domain (RGS2)
Analyse The crystal structure of the human G-protein subunit alpha (GNAI3) in complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2V4Z
- Type
- protein
- Length
- 438 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-binding protein G(K) subunit alpha; Regulator of G-protein signaling 2
- UniProt
- P08754, P41220
- Ligands
- GDP, ALF, MG
- Pockets
- 4 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 57% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide-binding protein G(K) subunit alpha | protein | 316 | 52% helix, 13% strand | P08754 |
| B | Regulator of G-protein signaling 2 | protein | 122 | 71% helix, 0% strand | P41220 |
Ligands and binding sites
- GDP · Guanosine-5'-diphosphate · ligand · chains A
- ALF · Tetrafluoroaluminate ion · ligand · chains A
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1188 | 0.78 | 0.80 | 81 | empty |
| 2 | 154 | 0.74 | 0.92 | 31 | GDP, ALF, MG |
| 3 | 207 | 0.64 | 0.84 | 25 | empty |
| 4 | 53 | 0.43 | 0.83 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 822 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 2V4Z · The crystal structure of the human G-protein subunit alpha (GNAI3) in complex with an… · the same entry in another collection · chain A against A, TM-score 1.00
- P08754 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.99
- P41220 · AlphaFold monomer V2.0 prediction for regulator of G-protein signaling 2 (P41220) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08754
- Every structure of UniProt P41220
- Elsewhere: RCSB PDB 2V4Z · PDBe 2V4Z · UniProt P08754 · UniProt P41220
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