Research workbench
Active site mutant (D177->N) of glucose 6-phosphate dehydrogenase from leuconostoc mesenteroides complexed with substrate and NADPH
Analyse Active site mutant (D177->N) of glucose 6-phosphate dehydrogenase from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1E7Y
- Type
- protein
- Length
- 485 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glucose 6-phosphate 1-dehydrogenase
- EC
- 1.1.1.49
- UniProt
- P11411
- Ligands
- NDP, BG6, CA
- Pockets
- 3 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glucose 6-phosphate 1-dehydrogenase (EC 1.1.1.49) | protein | 485 | 40% helix, 20% strand | P11411 |
Ligands and binding sites
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · ligand · chains A
- BG6 · 6-O-phosphono-beta-D-glucopyranose · sugar · chains A
- CA · Calcium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 538 | 0.67 | 0.78 | 68 | BG6 |
| 2 | 67 | 0.36 | 0.77 | 17 | NDP |
| 3 | 89 | 0.36 | 0.75 | 15 | empty |
Compared structures
- 1E7Y · Active site mutant (D177->N) of glucose 6-phosphate dehydrogenase from leuconostoc… · the same entry in another collection · chain A against A, TM-score 1.00
- P11411 · AlphaFold monomer V2.0 prediction for glucose-6-phosphate 1-dehydrogenase (P11411) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11411
- Elsewhere: RCSB PDB 1E7Y · PDBe 1E7Y · UniProt P11411
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.