Research workbench
Crystal structure of the conjugated bile acid hydrolase from clostridium perfringens in complex with reaction products glycine and cholate
Analyse Crystal structure of the conjugated bile acid hydrolase from clostridium… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2RLC
- Type
- protein
- Length
- 328 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Choloylglycine hydrolase
- EC
- 3.5.1.24
- UniProt
- P54965
- Ligands
- CHD, GLY, SO4
- Pockets
- 3 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 20% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Choloylglycine hydrolase (EC 3.5.1.24) | protein | 328 | 20% helix, 34% strand | P54965 |
Ligands and binding sites
- CHD · Cholic acid · ligand · chains A
- GLY · Glycine · ligand · chains A
- SO4 · Sulfate ion · ion · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 320 | 0.68 | 0.82 | 38 | CHD, GLY |
| 2 | 71 | 0.38 | 0.78 | 24 | empty |
| 3 | 50 | 0.29 | 0.76 | 15 | empty |
Modifications
Observed in the structure: 9 modified (engineered, oxidation).
Compared structures
- 2RLC · Crystal Structure of the Conjugated Bile Acid Hydrolase from Clostridium perfringens in… · the same entry in another collection · chain A against A, TM-score 1.00
- P54965 · AlphaFold monomer V2.0 prediction for conjugated bile acid hydrolase (P54965) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P54965
- Elsewhere: RCSB PDB 2RLC · PDBe 2RLC · UniProt P54965
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