Research workbench
Structure of farnesyl protein transferase bound to pb-93
Analyse Structure of farnesyl protein transferase bound to pb-93 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2R2L
- Type
- protein
- Length
- 716 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Farnesyltransferase subunit alpha; Farnesyltransferase subunit beta
- EC
- 2.5.1.58
- UniProt
- Q5RKJ4, Q02293
- Ligands
- FPP, PB9, ZN
- Pockets
- 11 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 59% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Farnesyltransferase subunit alpha | protein | 315 | 68% helix, 1% strand | Q5RKJ4 |
| B | Farnesyltransferase subunit beta (EC 2.5.1.58) | protein | 401 | 52% helix, 6% strand | Q02293 |
Ligands and binding sites
- FPP · Farnesyl diphosphate · ligand · chains A, B
- PB9 · methyl 4-{[{(3S)-6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl}(pyridin-2-ylsulfonyl)amino]methyl}piperidine-1-carboxylate · ligand · chains A, B
- ZN · Zinc ion · metal · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 857 | 0.76 | 0.79 | 53 | FPP, PB9 |
| 2 | 84 | 0.74 | 0.97 | 24 | empty |
| 3 | 366 | 0.73 | 0.84 | 58 | empty |
| 4 | 219 | 0.62 | 0.82 | 26 | empty |
| 5 | 310 | 0.59 | 0.78 | 36 | empty |
Interfaces
1 interface between chains.
- A–B · 3474 Ų buried · 70 hydrogen bonds · protein-protein
Compared structures
- 2R2L · Structure of Farnesyl Protein Transferase bound to PB-93 · the same entry in another collection · chain A against A, TM-score 1.00
- Q02293 · AlphaFold monomer V2.0 prediction for protein farnesyltransferase subunit beta (Q02293) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5RKJ4
- Every structure of UniProt Q02293
- Elsewhere: RCSB PDB 2R2L · PDBe 2R2L · UniProt Q5RKJ4 · UniProt Q02293
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.