Research workbench
Crystal structure of the heptp catalytic domain C270S mutant crystallized in ammonium acetate
Analyse Crystal structure of the heptp catalytic domain C270S mutant crystallized in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2QDP
- Type
- protein
- Length
- 292 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein phosphatase non-receptor type 7
- EC
- 3.1.3.48
- UniProt
- P35236
- Ligands
- PO4
- Pockets
- 2 · best druggability 0.48
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) | protein | 292 | 38% helix, 20% strand | P35236 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 155 | 0.48 | 0.77 | 31 | empty |
| 2 | 72 | 0.38 | 0.78 | 15 | empty |
Compared structures
- 2QDP · Crystal structure of the HePTP catalytic domain C270S mutant crystallized in ammonium… · the same entry in another collection · chain A against A, TM-score 1.00
- P35236 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 7… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35236
- Elsewhere: RCSB PDB 2QDP · PDBe 2QDP · UniProt P35236
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