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Native structure of lyp

Analyse Native structure of lyp in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2QCJ
Type: protein
Length: 560 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosine-protein phosphatase non-receptor type 22
EC: 3.1.3.48
UniProt: Q9Y2R2
Pockets: 10 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 28% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48)	protein	280	28% helix, 18% strand	Q9Y2R2

Pockets

10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	463	0.66	0.78	49	empty
2	190	0.64	0.84	23	empty
3	191	0.58	0.81	29	empty
4	120	0.48	0.79	18	empty
5	99	0.48	0.80	24	empty

Interfaces

1 interface between chains.

A–B · 582 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

2QCJ · Native Structure of Lyp · the same entry in another collection · chain A against A, TM-score 1.00
Q9Y2R2 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 22… · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Y2R2
Elsewhere: RCSB PDB 2QCJ · PDBe 2QCJ · UniProt Q9Y2R2

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