Research workbench
Structural basis for cooperative assembly of the TGF-beta signaling complex
Analyse Structural basis for cooperative assembly of the TGF-beta signaling complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2PJY
- Type
- protein
- Length
- 299 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transforming growth factor beta-3; TGF-beta receptor type-2; TGF-beta receptor type-1
- EC
- 2.7.11.30
- UniProt
- P10600, P37173, P36897
- Pockets
- 1 · best druggability 0.45
Structure
x-ray diffraction · 3 distinct chains · 10% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transforming growth factor beta-3 | protein | 112 | 19% helix, 42% strand | P10600 |
| B | TGF-beta receptor type-2 (EC 2.7.11.30) | protein | 108 | 3% helix, 44% strand | P37173 |
| C | TGF-beta receptor type-1 (EC 2.7.11.30) | protein | 79 | 9% helix, 35% strand | P36897 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 84 | 0.45 | 0.80 | 17 | empty |
Interfaces
3 interfaces between chains.
- A–B · 507 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 490 Ų buried · 7 hydrogen bonds · protein-protein
- A–C · 301 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 15 disulfide (disulfide).
Compared structures
- 2PJY · Structural basis for cooperative assembly of the TGF-beta signaling complex · the same entry in another collection · chain A against A, TM-score 1.00
- P37173 · AlphaFold monomer V2.0 prediction for TGF-beta receptor type-2 (P37173) · a predicted model of the same protein · chain B against A, TM-score 0.94
- P36897 · AlphaFold monomer V2.0 prediction for TGF-beta receptor type-1 (P36897) · a predicted model of the same protein · chain C against A, TM-score 0.82
- P10600 · AlphaFold monomer V2.0 prediction for transforming growth factor beta-3 proprotein… · a predicted model of the same protein · chain A against A, TM-score 0.81
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10600
- Every structure of UniProt P37173
- Every structure of UniProt P36897
- Elsewhere: RCSB PDB 2PJY · PDBe 2PJY · UniProt P10600 · UniProt P37173 · UniProt P36897
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