Research workbench

Structural insights of yeast fatty acid synthase

Analyse Structural insights of yeast fatty acid synthase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2PFF
Type: protein
Length: 11,262 residues
Chains: 9
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fatty acid synthase subunit alpha; Fatty acid synthase subunit beta; Tail protein
EC: 2.3.1.86
UniProt: P19097, P07149
Pockets: 20 · best druggability 0.85

Structure

x-ray diffraction · 3 distinct chains · 25% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, D, G	Fatty acid synthase subunit alpha (EC 2.3.1.86)	protein	1683	26% helix, 4% strand	P19097
B, E, H	Fatty acid synthase subunit beta (EC 2.3.1.86)	protein	2006	25% helix, 5% strand	P07149
C, F, I	Tail protein	protein	65	23% helix, 5% strand	—

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	917	0.85	0.87	136	empty
2	843	0.85	0.87	159	empty
3	886	0.84	0.86	138	empty
4	989	0.84	0.86	140	empty
5	843	0.84	0.87	141	empty

Interfaces

15 interfaces between chains.

D–E · 1135 Å² buried · 4 hydrogen bonds · protein-protein
G–H · 1134 Å² buried · 5 hydrogen bonds · protein-protein
A–B · 1126 Å² buried · 5 hydrogen bonds · protein-protein
H–I · 889 Å² buried · 10 hydrogen bonds · protein-protein
E–F · 878 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

2PFF · Structural Insights of Yeast Fatty Acid Synthase · the same entry in another collection · chain I against I, TM-score 1.00
P07149 · AlphaFold monomer V2.0 prediction for fatty acid synthase subunit beta (P07149) · a predicted model of the same protein · chain H against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P19097
Every structure of UniProt P07149
Elsewhere: RCSB PDB 2PFF · PDBe 2PFF · UniProt P19097 · UniProt P07149

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.