UniProt P07149
Fatty acid synthase subunit beta (P07149)
Fatty acid synthase subunit beta (UniProt P07149), EC 1.3.1.9, 2.3.1.38: 28 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 177 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P07149
- Protein
- Fatty acid synthase subunit beta
- EC
- 1.3.1.9, 2.3.1.38, 2.3.1.39, 2.3.1.86, 3.1.2.14, 4.2.1.59
- Experimental structures
- 28
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 177 · 17 records with a druggable one
Structures
29 records of P07149 in the MolNFT archive: 28 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2PFF | Structural Insights of Yeast Fatty Acid Synthase | x-ray diffraction | B, E, H | — | — |
| 2PFF | Structural insights of yeast fatty acid synthase | x-ray diffraction | B, E, H | — | — |
| 2UV8 | Crystal structure of yeast fatty acid synthase with stalled acyl carrier protein at 3.1 angstrom… | x-ray diffraction | G, H, I | — | — |
| 2UV8 | Crystal structure of yeast fatty acid synthase with stalled acyl carrier protein at 3.1 ångström… | x-ray diffraction | G, H, I | — | — |
| 2VKZ | Structure of the cerulenin-inhibited fungal fatty acid synthase type I multienzyme complex | x-ray diffraction | G, H, I | — | — |
| 2VKZ | Structure of the cerulenin-inhibited fungal fatty acid synthase type I multienzyme complex | x-ray diffraction | G, H, I | — | — |
| 3HMJ | Saccharomyces cerevisiae FAS type I | x-ray diffraction | G, H, I | — | — |
| 3HMJ | Saccharomyces cerevisiae fas type I | x-ray diffraction | G, H, I | — | — |
| 6QL6 | Structure of Fatty acid synthase complex from Saccharomyces cerevisiae at 2.9 Angstrom | electron microscopy | G, H, I, J, K, L | FMN | 8 (best 0.80) |
| 6QL7 | Structure of fatty acid synthase complex with bound gamma subunit from Saccharomyces cerevisiae at… | x-ray diffraction | G, H, I, J, K, L, g, h, i, j, k, l | — | 6 (best 0.87) |
| 6QL9 | Structure of Fatty acid synthase complex from Saccharomyces cerevisiae at 2.9 Angstrom | x-ray diffraction | G, H, I, J, K, L | NA, FMN | 7 (best 0.80) |
| 6TA1 | Fatty acid synthase of S. cerevisiae | electron microscopy | G, C, E, L, H, J | FMN | 7 (best 0.81) |
| 6U5T | Electron cryomicroscopy Structure of S. cerevisiae FAS in the Apo state | electron microscopy | G | FMN | 13 (best 0.81) |
| 6U5T | Electron cryomicroscopy structure of S. cerevisiae fas in the apo state | electron microscopy | G | FMN | — |
| 6U5U | Electron cryomicroscopy structure of S. cerevisiae fas in the ks- stalled state | electron microscopy | G | FMN, NAP | — |
| 6WC7 | Acyl carrier protein (ACP) domain bound to dehydratase (DH) domain in fungal fatty acid synthase… | electron microscopy | G | — | 5 (best 0.80) |
| 6WC7 | Acyl carrier protein (acp) domain bound to dehydratase (dh) domain in fungal fatty acid synthase… | electron microscopy | G | — | — |
| 8PRW | Cryo-EM structure of the yeast fatty acid synthase at 1.9 angstrom resolution | electron microscopy | G, J, I, H, K, L | COA, FNR, NAP | 8 (best 0.78) |
| 8PS1 | Asymmetric unit of the yeast fatty acid synthase in the non-rotated state with ACP at the… | electron microscopy | G | FMN, COA, NAP | 13 (best 0.79) |
| 8PS2 | Asymmetric unit of the yeast fatty acid synthase with ACP at the enoyl reductase domain (FASam… | electron microscopy | G | A3Z, FMN, MLC | 13 (best 0.87) |
| 8PS8 | Asymmetric unit of the yeast fatty acid synthase in the semi non-rotated state with ACP at the… | electron microscopy | G | — | 13 (best 0.85) |
| 8PS9 | Asymmetric unit of the yeast fatty acid synthase in the non-rotated state with ACP at the… | electron microscopy | G | FMN, MLC | 12 (best 0.80) |
| 8PSA | Asymmetric unit of the yeast fatty acid synthase in the semi non-rotated state with ACP at the… | electron microscopy | G | FMN | 13 (best 0.81) |
| 8PSF | Asymmetric unit of the yeast fatty acid synthase in non-rotated state with ACP at the acetyl… | electron microscopy | G | PNS, FMN | 13 (best 0.79) |
| 8PSG | Asymmetric unit of the yeast fatty acid synthase in the semi non-rotated state with ACP at the… | electron microscopy | G | FMN | 12 (best 0.79) |
| 8PSJ | Asymmetric unit of the yeast fatty acid synthase in the semi rotated state with ACP at the acetyl… | electron microscopy | G | PNS, FMN | 11 (best 0.83) |
| 8PSK | Asymmetric unit of the yeast fatty acid synthase in the non-rotated state with ACP at the… | electron microscopy | G | FMN | 11 (best 0.80) |
| 8PSL | Asymmetric unit of the yeast fatty acid synthase in the semi non-rotated state with ACP at the… | electron microscopy | G | FMN | 12 (best 0.80) |
| P07149 | AlphaFold monomer V2.0 prediction for fatty acid synthase subunit beta (P07149) | predicted | A | — | — |
Ligands
- FMN · Flavin mononucleotide · in 15 records
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · in 3 records
- COA · Coenzyme A · in 2 records
- MLC · Malonyl-coenzyme A · in 2 records
- PNS · 4'-phosphopantetheine · in 2 records
- A3Z · ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (~{E})-but-2-enethioate · in 1 record
- FNR · 1-deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydro-2H-benzo[g]pteridin-1-id-10(5H)-yl)-5-O-phosphonato-D-ribitol · in 1 record
- NA · Sodium ion · in 1 record
Experiment against prediction
- 6WC7 chain G against the predicted model P07149: TM-score 0.95, RMSD 1.68 Å
- 6WC7 chain G against the predicted model P07149: TM-score 0.95, RMSD 1.68 Å
- 2VKZ chain I against the predicted model P07149: TM-score 0.95, RMSD 3.34 Å
- 2VKZ chain I against the predicted model P07149: TM-score 0.95, RMSD 3.34 Å
- 3HMJ chain I against the predicted model P07149: TM-score 0.95, RMSD 3.34 Å
- 3HMJ chain I against the predicted model P07149: TM-score 0.95, RMSD 3.34 Å
- 8PSJ chain G against the predicted model P07149: TM-score 0.95, RMSD 3.23 Å
- 2UV8 chain H against the predicted model P07149: TM-score 0.95, RMSD 3.43 Å
- 2UV8 chain H against the predicted model P07149: TM-score 0.95, RMSD 3.43 Å
- 6QL9 chain L against the predicted model P07149: TM-score 0.95, RMSD 3.48 Å
Elsewhere
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