MolNFT v1 · #165760 · protein
Electron cryomicroscopy structure of S. cerevisiae fas in the apo state
6U5T · Fatty acid synthase subunit alpha: “Electron cryomicroscopy structure of S. cerevisiae fas in the apo state”. Electron microscopy, 2 ligands (PNS, FMN), 20 pockets (best druggability 0.81). MolNFT v1 #165760 on GenesisL1: 3D…
- PDB
- 6U5T
- Type
- protein
- Length
- 3,649 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fatty acid synthase subunit alpha; Fatty acid synthase subunit beta
- EC
- 2.3.1.86, 1.1.1.100, 2.3.1.41, 4.2.1.59, 1.3.1.9, 2.3.1.38, 2.3.1.39, 3.1.2.14
- UniProt
- A0A140KF01, P07149
- Ligands
- PNS, FMN
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · 2 distinct chains · 41% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fatty acid synthase subunit alpha (EC 2.3.1.86, 1.1.1.100, 2.3.1.41) | protein | 1616 | 44% helix, 10% strand | A0A140KF01 |
| G | Fatty acid synthase subunit beta (EC 2.3.1.86, 4.2.1.59, 1.3.1.9, 2.3.1.38, 2.3.1.39, 3.1.2.14) | protein | 2033 | 38% helix, 18% strand | P07149 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 962 | 0.81 | 0.83 | 92 | FMN |
| 2 | 890 | 0.79 | 0.81 | 118 | empty |
| 3 | 585 | 0.76 | 0.83 | 71 | empty |
| 4 | 282 | 0.75 | 0.87 | 38 | empty |
| 5 | 414 | 0.73 | 0.83 | 43 | empty |
Interfaces
1 interface between chains.
- A–G · 5384 Ų buried · 74 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 cofactor (phosphopantetheinylation).
Compared structures
- 6U5T · Electron cryomicroscopy Structure of S. cerevisiae FAS in the Apo state · the same entry in another collection · chain A against A, TM-score 1.00
- P07149 · AlphaFold monomer V2.0 prediction for fatty acid synthase subunit beta (P07149) · a predicted model of the same protein · chain G against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A140KF01
- Every structure of UniProt P07149
- Elsewhere: RCSB PDB 6U5T · PDBe 6U5T · UniProt A0A140KF01 · UniProt P07149
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