Research workbench
Structure of the SKP1-FBW7 complex
Analyse Structure of the SKP1-FBW7 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2OVP
- Type
- protein
- Length
- 575 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- S-phase kinase-associated protein 1A; F-BOX/WD repeat protein 7
- UniProt
- P63208, Q969H0
- Pockets
- 2 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 24% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | S-phase kinase-associated protein 1A | protein | 134 | 54% helix, 10% strand | P63208 |
| B | F-BOX/WD repeat protein 7 | protein | 441 | 15% helix, 41% strand | Q969H0 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 607 | 0.73 | 0.81 | 78 | empty |
| 2 | 70 | 0.37 | 0.78 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1776 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 2OVP · Structure of the Skp1-Fbw7 complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q969H0 · AlphaFold monomer V2.0 prediction for F-BOX/WD repeat-containing protein 7 (Q969H0) · a predicted model of the same protein · chain B against A, TM-score 0.95
- P63208 · AlphaFold monomer V2.0 prediction for S-phase kinase-associated protein 1 (P63208) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63208
- Every structure of UniProt Q969H0
- Elsewhere: RCSB PDB 2OVP · PDBe 2OVP · UniProt P63208 · UniProt Q969H0
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