Calmodulin-smooth muscle light chain kinase peptide complex

Structure

x-ray diffraction · 2 distinct chains · 61% helix, 5% strand (DSSP).

Ligands and binding sites

• ACE · Acetyl group · ligand · chains B
• CA · Calcium ion · metal · 4 copies · chains A
• NH2 · Amino group · ion · chains A, B
• SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 1510 Ų buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 covalent (covalent ligand).

Compared structures

• 2O5G · Calmodulin-smooth muscle light chain kinase peptide complex · the same entry in another collection · chain A against A, TM-score 1.00
• P11799 · AlphaFold monomer V2.0 prediction for myosin light chain kinase, smooth muscle (P11799) · a predicted model of the same protein · chain B against A, TM-score 0.77
• P62149 · AlphaFold monomer V2.0 prediction for calmodulin (P62149) · a predicted model of the same protein · chain A against A, TM-score 0.50

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P62149
• Every structure of UniProt P11799
• Elsewhere: RCSB PDB 2O5G · PDBe 2O5G · UniProt P62149 · UniProt P11799