Crystal structure of type 1 human methionine aminopeptidase in complex with 3-(2,2-DIMETHYLPROPIONYLAMINO)PYRIDINE-2-carboxylic acid thiazole-2-ylamide

Structure

x-ray diffraction · 1 distinct chain · 27% helix, 22% strand (DSSP).

Ligands and binding sites

• HM5 · 3-[(2,2-dimethylpropanoyl)amino]-N-1,3-thiazol-2-ylpyridine-2-carboxamide · ligand · chains A
• CO · Cobalt (II) ion · metal · 3 copies · chains A
• K · Potassium ion · metal · chains A
• GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Compared structures

• 2NQ7 · Crystal structure of type 1 human methionine aminopeptidase in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
• P53582 · AlphaFold monomer V2.0 prediction for methionine aminopeptidase 1 (P53582) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P53582
• Elsewhere: RCSB PDB 2NQ7 · PDBe 2NQ7 · UniProt P53582