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Crystal structure of the btb domain from the LRF/ZBTB7 transcriptional regulator

Analyse Crystal structure of the btb domain from the LRF/ZBTB7 transcriptional regulator in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2NN2
Type: protein
Length: 234 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Zinc finger and btb domain-containing protein 7A
UniProt: O95365
Pockets: 2 · best druggability 0.32

Structure

x-ray diffraction · 1 distinct chain · 55% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Zinc finger and btb domain-containing protein 7A	protein	117	55% helix, 18% strand	O95365

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	54	0.32	0.77	16	empty
2	74	0.32	0.74	16	empty

Interfaces

1 interface between chains.

A–B · 1661 Å² buried · 23 hydrogen bonds · protein-protein

Compared structures

2NN2 · Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator · the same entry in another collection · chain A against A, TM-score 1.00
O95365 · AlphaFold monomer V2.0 prediction for zinc finger and btb domain- containing protein 7A… · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O95365
Elsewhere: RCSB PDB 2NN2 · PDBe 2NN2 · UniProt O95365

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