UniProt O95365
Zinc finger and BTB domain-containing protein 7A (O95365)
Zinc finger and BTB domain-containing protein 7A (UniProt O95365): 19 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 56 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O95365
- Protein
- Zinc finger and BTB domain-containing protein 7A
- Experimental structures
- 19
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 56 · 10 records with a druggable one
Structures
20 records of O95365 in the MolNFT archive: 19 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2IF5 | Structure of the POZ domain of human LRF, a master regulator of oncogenesis | x-ray diffraction | A | PR | — |
| 2IF5 | Structure of the poz domain of human lrf, a master regulator of oncogenesis | x-ray diffraction | A | — | — |
| 2NN2 | Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator | x-ray diffraction | A, B | — | 2 (best 0.32) |
| 2NN2 | Crystal structure of the btb domain from the LRF/ZBTB7 transcriptional regulator | x-ray diffraction | A, B | — | — |
| 7EYI | Crystal structure of ZBTB7A in complex with gamma-globin -200 sequence element with C-194A mutation | x-ray diffraction | G, H | ZN, BO3 | 7 (best 0.80) |
| 7EYI | Crystal structure of ZBTB7A in complex with gamma-globin -200 sequence element with C-194A mutation | x-ray diffraction | G, H | ZN, BO3 | — |
| 7N5S | ZBTB7A Zinc Finger Domain Bound to -200 Site of Fetal Globin Promoter (Oligo 6) | x-ray diffraction | A | ZN | 2 (best 0.78) |
| 7N5S | ZBTB7A zinc finger domain bound to -200 site of fetal globin promoter (oligo 6) | x-ray diffraction | A | ZN | — |
| 7N5T | ZBTB7A Zinc Finger Domain Bound to -200 Site of Fetal Globin Promoter (Oligo 5) | x-ray diffraction | A | ZN | 2 (best 0.78) |
| 7N5T | ZBTB7A zinc finger domain bound to -200 site of fetal globin promoter (oligo 5) | x-ray diffraction | A | ZN | — |
| 7N5U | ZBTB7A Zinc Finger Domain Bound to DNA Duplex Containing GGACCC (Oligo 21) | x-ray diffraction | A | ZN | 2 (best 0.72) |
| 7N5U | ZBTB7A zinc finger domain bound to DNA duplex containing ggaccc (oligo 21) | x-ray diffraction | A | ZN | — |
| 7N5V | ZBTB7A Zinc Finger Domain Bound to DNA Duplex Containing GGACCC (Oligo 20) | x-ray diffraction | A, B, F | ZN | 10 (best 0.78) |
| 7N5V | ZBTB7A zinc finger domain bound to DNA duplex containing ggaccc (oligo 20) | x-ray diffraction | A, B, F | ZN | — |
| 7N5W | ZBTB7A Zinc Finger Domain Bound to DNA Duplex Containing GGACCC (Oligo 23) | x-ray diffraction | A | ZN | 3 (best 0.62) |
| 7N5W | ZBTB7A zinc finger domain bound to DNA duplex containing ggaccc (oligo 23) | x-ray diffraction | A | ZN | — |
| 8E3D | ZBTB7A Zinc Finger Domain Bound to DNA Duplex Containing CAST sequence (#11) | x-ray diffraction | A, B, F | ZN | 7 (best 0.82) |
| 8E3E | ZBTB7A Zinc Finger Domain Bound to DNA Duplex Containing CAST sequence (#10) | x-ray diffraction | A, B, F | ZN | 10 (best 0.80) |
| 8H9H | Crystal structure of ZBTB7A in complex with GACCC-containing sequence | x-ray diffraction | G, F | ZN | 4 (best 0.74) |
| O95365 | AlphaFold monomer V2.0 prediction for zinc finger and btb domain- containing protein 7A (O95365) | predicted | A | — | 7 (best 0.69) |
Ligands
Experiment against prediction
- 2IF5 chain A against the predicted model O95365: TM-score 0.91, RMSD 1.24 Å
- 2IF5 chain A against the predicted model O95365: TM-score 0.91, RMSD 1.24 Å
- 2NN2 chain A against the predicted model O95365: TM-score 0.89, RMSD 1.30 Å
- 2NN2 chain A against the predicted model O95365: TM-score 0.89, RMSD 1.30 Å
- 7N5V chain F against the predicted model O95365: TM-score 0.81, RMSD 1.33 Å
- 8H9H chain F against the predicted model O95365: TM-score 0.81, RMSD 0.45 Å
- 8H9H chain G against the predicted model O95365: TM-score 0.80, RMSD 1.90 Å
- 7N5U chain A against the predicted model O95365: TM-score 0.79, RMSD 1.91 Å
- 7N5U chain A against the predicted model O95365: TM-score 0.79, RMSD 1.91 Å
- 7N5V chain A against the predicted model O95365: TM-score 0.77, RMSD 1.49 Å
Elsewhere
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