MolNFT v1 · #182832 · protein + DNA
ZBTB7A zinc finger domain bound to DNA duplex containing ggaccc (oligo 23)
7N5W · Zinc finger and btb domain-containing protein 7A: “ZBTB7A zinc finger domain bound to DNA duplex containing ggaccc (oligo 23)”. X-ray diffraction, 1 ligand (ZN), 3 pockets (best druggability 0.62). MolNFT v1 #182832 on GenesisL1: 3D…
- PDB
- 7N5W
- Type
- protein + DNA
- Length
- 117 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Zinc finger and btb domain-containing protein 7A; DNA strand I; DNA strand II
- UniProt
- O95365
- Ligands
- ZN
- Pockets
- 3 · best druggability 0.62
Structure
x-ray diffraction · 3 distinct chains · 33% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Zinc finger and btb domain-containing protein 7A | protein | 85 | 33% helix, 16% strand | O95365 |
| X | DNA strand I | dna | 16 | — | — |
| Y | DNA strand II | dna | 16 | — | — |
Ligands and binding sites
- ZN · Zinc ion · metal · 3 copies · chains A
- EDO · 1,2-ethanediol · additive · 4 copies · chains A, X, Y
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 90 | 0.62 | 0.89 | 13 | empty |
| 2 | 173 | 0.50 | 0.78 | 32 | empty |
| 3 | 54 | 0.30 | 0.76 | 16 | empty |
Interfaces
3 interfaces between chains.
- X–Y · 664 Ų buried · 63 hydrogen bonds · nucleic-nucleic
- A–X · 503 Ų buried · 15 hydrogen bonds · protein-nucleic
- A–Y · 349 Ų buried · 5 hydrogen bonds · protein-nucleic
Compared structures
- 7N5W · ZBTB7A Zinc Finger Domain Bound to DNA Duplex Containing GGACCC (Oligo 23) · the same entry in another collection · chain A against A, TM-score 1.00
- O95365 · AlphaFold monomer V2.0 prediction for zinc finger and btb domain- containing protein 7A… · a predicted model of the same protein · chain A against A, TM-score 0.56
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95365
- Elsewhere: RCSB PDB 7N5W · PDBe 7N5W · UniProt O95365
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