MolNFT v1 · #177920 · protein + DNA
Crystal structure of ZBTB7A in complex with gamma-globin -200 sequence element with C-194A mutation
7EYI · Zinc finger and btb domain-containing protein 7A: “Crystal structure of ZBTB7A in complex with gamma-globin -200 sequence element with C-194A mutation”. X-ray diffraction, 2 ligands (ZN, BO3), 7 pockets (best druggability 0.80).…
- PDB
- 7EYI
- Type
- protein + DNA
- Length
- 291 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Zinc finger and btb domain-containing protein 7A; DNA (5'…
- UniProt
- O95365
- Ligands
- ZN, BO3
- Pockets
- 7 · best druggability 0.80
Structure
x-ray diffraction · 6 distinct chains · 36% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| G | Zinc finger and btb domain-containing protein 7A | protein | 111 | 38% helix, 16% strand | O95365 |
| H | Zinc finger and btb domain-containing protein 7A | protein | 112 | 34% helix, 16% strand | O95365 |
| A | DNA (5'- D(*AP*TP*AP*GP*GP*GP*CP*CP*CP*CP*TP*TP*CP*CP*CP*AP*AP*C)-3') | dna | 16 | — | — |
| B | DNA (5'- D(*TP*GP*TP*TP*GP*GP*GP*AP*AP*GP*GP*GP*GP*CP*CP*CP*TP*A)-3') | dna | 16 | — | — |
| C | DNA (5'- D(*AP*TP*AP*GP*GP*GP*CP*CP*CP*CP*TP*TP*CP*CP*CP*AP*AP*C)-3') | dna | 18 | — | — |
| D | DNA (5'- D(*TP*GP*TP*TP*GP*GP*GP*AP*AP*GP*GP*GP*GP*CP*CP*CP*TP*A)-3') | dna | 18 | — | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 412 | 0.80 | 0.88 | 46 | empty |
| 2 | 227 | 0.74 | 0.89 | 37 | BO3 |
| 3 | 750 | 0.69 | 0.77 | 60 | empty |
| 4 | 99 | 0.61 | 0.88 | 16 | empty |
| 5 | 84 | 0.53 | 0.85 | 15 | empty |
Interfaces
12 interfaces between chains.
- G–B · 949 Ų buried · 25 hydrogen bonds · protein-nucleic
- H–D · 884 Ų buried · 23 hydrogen bonds · protein-nucleic
- G–A · 776 Ų buried · 11 hydrogen bonds · protein-nucleic
- H–C · 775 Ų buried · 13 hydrogen bonds · protein-nucleic
- C–D · 767 Ų buried · 71 hydrogen bonds · nucleic-nucleic
Compared structures
- 7EYI · Crystal structure of ZBTB7A in complex with gamma-globin -200 sequence element with… · the same entry in another collection · chain D against D, TM-score 1.00
- O95365 · AlphaFold monomer V2.0 prediction for zinc finger and btb domain- containing protein 7A… · a predicted model of the same protein · chain G against A, TM-score 0.74
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95365
- Elsewhere: RCSB PDB 7EYI · PDBe 7EYI · UniProt O95365
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