Research workbench
Crystal structures of organomercurial-activated chicken liver dihydrofolate reductase complexes
Analyse Crystal structures of organomercurial-activated chicken liver dihydrofolate… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1DR4
- Type
- protein
- Length
- 186 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dihydrofolate reductase
- EC
- 1.5.1.3
- UniProt
- P00378
- Ligands
- NAP, HBI, HG, CA
- Pockets
- 2 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 23% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dihydrofolate reductase (EC 1.5.1.3) | protein | 186 | 23% helix, 32% strand | P00378 |
Ligands and binding sites
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · chains A
- HBI · 7,8-dihydrobiopterin · ligand · chains A
- HG · Mercury (II) ion · metal · chains A
- CA · Calcium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 451 | 0.72 | 0.82 | 45 | NAP, HBI |
| 2 | 53 | 0.29 | 0.75 | 11 | empty |
Compared structures
- 1DR4 · Crystal structures of organomercurial-activated chicken liver dihydrofolate reductase… · the same entry in another collection · chain A against A, TM-score 1.00
- P00378 · AlphaFold monomer V2.0 prediction for dihydrofolate reductase (P00378) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00378
- Elsewhere: RCSB PDB 1DR4 · PDBe 1DR4 · UniProt P00378
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