UniProt P00378
P00378
P00378 (UniProt P00378): 15 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P00378
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 2
Structures
16 records of P00378 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DR1 | 2.2 ångströms crystal structure of chicken liver dihydrofolate reductase complexed with NADP+ and… | x-ray diffraction | A | — | — |
| 1DR1 | 2.2 ångströms crystal structure of chicken liver dihydrofolate reductase complexed with NADP+ and… | x-ray diffraction | A | — | — |
| 1DR2 | 2.3 ångströms crystal structure of chicken liver dihydrofolate reductase complexed with thionadp+… | x-ray diffraction | A | — | — |
| 1DR2 | 2.3 ångströms crystal structure of chicken liver dihydrofolate reductase complexed with thionadp+… | x-ray diffraction | A | — | — |
| 1DR3 | 2.3 ångströms crystal structure of chicken liver dihydrofolate reductase complexed with thionadp+… | x-ray diffraction | A | — | — |
| 1DR3 | 2.3 ångströms crystal structure of chicken liver dihydrofolate reductase complexed with thionadp+… | x-ray diffraction | A | — | — |
| 1DR4 | Crystal structures of organomercurial-activated chicken liver dihydrofolate reductase complexes | x-ray diffraction | A | — | — |
| 1DR4 | Crystal structures of organomercurial-activated chicken liver dihydrofolate reductase complexes | x-ray diffraction | A | — | — |
| 1DR5 | Crystal structures of organomercurial-activated chicken liver dihydrofolate reductase complexes | x-ray diffraction | A | — | — |
| 1DR5 | Crystal structures of organomercurial-activated chicken liver dihydrofolate reductase complexes | x-ray diffraction | A | — | — |
| 1DR6 | Crystal structures of organomercurial-activated chicken liver dihydrofolate reductase complexes | x-ray diffraction | A | — | — |
| 1DR6 | Crystal structures of organomercurial-activated chicken liver dihydrofolate reductase complexes | x-ray diffraction | A | — | — |
| 1DR7 | Crystal structures of organomercurial-activated chicken liver dihydrofolate reductase complexes | x-ray diffraction | A | — | — |
| 1DR7 | Crystal structures of organomercurial-activated chicken liver dihydrofolate reductase complexes | x-ray diffraction | A | — | — |
| 8DFR | Refined crystal structures of chicken liver dihydrofolate reductase. 3 ångströms apo-enzyme and 1.7… | x-ray diffraction | A | CA, NDP | — |
| P00378 | AlphaFold monomer V2.0 prediction for dihydrofolate reductase (P00378) | predicted | A | — | — |
Ligands
Experiment against prediction
- 1DR1 chain A against the predicted model P00378: TM-score 0.99, RMSD 0.67 Å
- 1DR1 chain A against the predicted model P00378: TM-score 0.99, RMSD 0.67 Å
- 1DR4 chain A against the predicted model P00378: TM-score 0.98, RMSD 0.68 Å
- 1DR4 chain A against the predicted model P00378: TM-score 0.98, RMSD 0.68 Å
- 1DR6 chain A against the predicted model P00378: TM-score 0.98, RMSD 0.70 Å
- 1DR6 chain A against the predicted model P00378: TM-score 0.98, RMSD 0.70 Å
- 1DR5 chain A against the predicted model P00378: TM-score 0.98, RMSD 0.69 Å
- 1DR5 chain A against the predicted model P00378: TM-score 0.98, RMSD 0.69 Å
- 8DFR chain A against the predicted model P00378: TM-score 0.98, RMSD 0.70 Å
- 1DR3 chain A against the predicted model P00378: TM-score 0.98, RMSD 0.70 Å
Elsewhere
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