Research workbench
N domain of cardiac troponin C bound to the switch fragment of fast skeletal troponin I at pH 6
Analyse N domain of cardiac troponin C bound to the switch fragment of fast skeletal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2MKP
- Type
- protein
- Length
- 106 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Troponin C, slow skeletal and cardiac muscles; Troponin I, fast skeletal muscle
- UniProt
- P63316, P48788
- Ligands
- CA
- Pockets
- 1 · best druggability 0.40
Structure
solution nmr · 2 distinct chains · 45% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Troponin C, slow skeletal and cardiac muscles | protein | 89 | 47% helix, 2% strand | P63316 |
| I | Troponin I, fast skeletal muscle | protein | 17 | 35% helix, 0% strand | P48788 |
Ligands and binding sites
- CA · Calcium ion · metal · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 90 | 0.40 | 0.77 | 17 | empty |
Interfaces
1 interface between chains.
- C–I · 789 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 2MKP · N domain of cardiac troponin C bound to the switch fragment of fast skeletal troponin I… · the same entry in another collection · chain C against C, TM-score 1.00
- P63316 · AlphaFold monomer V2.0 prediction for troponin C, slow skeletal and cardiac muscles… · a predicted model of the same protein · chain C against A, TM-score 0.87
- P48788 · AlphaFold monomer V2.0 prediction for troponin I, fast skeletal muscle (P48788) · a predicted model of the same protein · chain I against A, TM-score 0.44
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63316
- Every structure of UniProt P48788
- Elsewhere: RCSB PDB 2MKP · PDBe 2MKP · UniProt P63316 · UniProt P48788
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