Research workbench
Cooperative structure of the heterotrimeric pre-mRNA retention and splicing complex
Analyse Cooperative structure of the heterotrimeric pre-mRNA retention and splicing… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2MKC
- Type
- protein
- Length
- 174 residues
- Chains
- 3
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- U2 snrnp component IST3; Pre-mRNA leakage protein 1; Pre-mRNA-splicing factor CWC26
- UniProt
- P40565, Q07930, P46947
- Pockets
- 1 · best druggability 0.50
Structure
solution nmr · 3 distinct chains · 23% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | U2 snrnp component IST3 | protein | 118 | 31% helix, 25% strand | P40565 |
| B | Pre-mRNA leakage protein 1 | protein | 23 | 17% helix, 0% strand | Q07930 |
| C | Pre-mRNA-splicing factor CWC26 | protein | 33 | 0% helix, 0% strand | P46947 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 127 | 0.50 | 0.80 | 19 | empty |
Interfaces
3 interfaces between chains.
- A–C · 944 Ų buried · 22 hydrogen bonds · protein-protein
- A–B · 857 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 107 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 2MKC · Cooperative Structure of the Heterotrimeric pre-mRNA Retention and Splicing Complex · the same entry in another collection · chain A against A, TM-score 1.00
- P40565 · AlphaFold monomer V2.0 prediction for U2 snrnp component IST3 (P40565) · a predicted model of the same protein · chain A against A, TM-score 0.83
- P46947 · AlphaFold monomer V2.0 prediction for pre-mRNA-splicing factor CWC26 (P46947) · a predicted model of the same protein · chain C against A, TM-score 0.48
- Q07930 · AlphaFold monomer V2.0 prediction for pre-mRNA leakage protein 1 (Q07930) · a predicted model of the same protein · chain B against A, TM-score 0.26
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P40565
- Every structure of UniProt Q07930
- Every structure of UniProt P46947
- Elsewhere: RCSB PDB 2MKC · PDBe 2MKC · UniProt P40565 · UniProt Q07930 · UniProt P46947
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