UniProt P46947
Pre-mRNA-splicing factor CWC26 (P46947)
Pre-mRNA-splicing factor CWC26 (UniProt P46947): 12 experimental structures and 1 predicted model on GenesisL1, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P46947
- Protein
- Pre-mRNA-splicing factor CWC26
- Experimental structures
- 12
- Predicted models
- 1
- Pockets
- 7 · 5 records with a druggable one
Structures
13 records of P46947 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2MKC | Cooperative Structure of the Heterotrimeric pre-mRNA Retention and Splicing Complex | solution nmr | C | — | 1 (best 0.50) |
| 2MKC | Cooperative structure of the heterotrimeric pre-mRNA retention and splicing complex | solution nmr | C | — | 1 (best 0.50) |
| 2MY2 | Snu17p-Bud13p structure intermediate during RES complex assembly | solution nmr | B | — | 1 (best 0.49) |
| 2MY2 | SNU17P-BUD13P structure intermediate during res complex assembly | solution nmr | B | — | 1 (best 0.49) |
| 4UQT | RRM-peptide structure in RES complex | solution nmr | B | — | — |
| 4UQT | Rrm-peptide structure in res complex | solution nmr | B | — | — |
| 5GM6 | Cryo-EM structure of the activated spliceosome (Bact complex) at 3.5 angstrom resolution | electron microscopy | W | — | 1 (best 0.85) |
| 5LQW | yeast activated spliceosome | electron microscopy | L | — | — |
| 5LQW | Yeast activated spliceosome | electron microscopy | L | — | — |
| 5ZWM | Cryo-EM structure of the yeast pre-B complex at an average resolution of 3.4~4.6 angstrom… | electron microscopy | Y | — | — |
| 5ZWO | Cryo-EM structure of the yeast B complex at average resolution of 3.9 angstrom | electron microscopy | Y | — | 1 (best 0.80) |
| 5ZWO | Cryo-EM structure of the yeast B complex at average resolution of 3.9 ångström | electron microscopy | Y | — | 1 (best 0.80) |
| P46947 | AlphaFold monomer V2.0 prediction for pre-mRNA-splicing factor CWC26 (P46947) | predicted | A | — | — |
Experiment against prediction
- 5LQW chain L against the predicted model P46947: TM-score 0.78, RMSD 1.15 Å
- 5LQW chain L against the predicted model P46947: TM-score 0.78, RMSD 1.15 Å
- 5ZWM chain Y against the predicted model P46947: TM-score 0.58, RMSD 2.31 Å
- 5ZWO chain Y against the predicted model P46947: TM-score 0.58, RMSD 2.31 Å
- 5ZWO chain Y against the predicted model P46947: TM-score 0.58, RMSD 2.31 Å
- 5GM6 chain W against the predicted model P46947: TM-score 0.57, RMSD 2.45 Å
- 2MKC chain C against the predicted model P46947: TM-score 0.48, RMSD 2.81 Å
- 2MKC chain C against the predicted model P46947: TM-score 0.48, RMSD 2.81 Å
- 4UQT chain B against the predicted model P46947: TM-score 0.36, RMSD 2.37 Å
- 4UQT chain B against the predicted model P46947: TM-score 0.36, RMSD 2.37 Å
Elsewhere
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