Research workbench
Backbone 1H, 13C, 15N resonance assignments of calcium-bound calmodulin in complex with PSD95 N-terminal peptide
Analyse Backbone 1H, 13C, 15N resonance assignments of calcium-bound calmodulin in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2MES
- Type
- protein
- Length
- 163 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calmodulin; Disks large homolog 4
- UniProt
- P62155, P78352
- Ligands
- CA
- Pockets
- 3 · best druggability 0.62
Structure
solution nmr · 2 distinct chains · 58% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calmodulin | protein | 144 | 56% helix, 6% strand | P62155 |
| B | Disks large homolog 4 | protein | 19 | 74% helix, 0% strand | P78352 |
Ligands and binding sites
- CA · Calcium ion · metal · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 113 | 0.62 | 0.87 | 24 | empty |
| 2 | 53 | 0.52 | 0.88 | 14 | empty |
| 3 | 53 | 0.31 | 0.75 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1269 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 2MES · Backbone 1H, 13C, 15N resonance assignments of calcium-bound calmodulin in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
- P78352 · AlphaFold monomer V2.0 prediction for disks large homolog 4 (P78352) · a predicted model of the same protein · chain B against A, TM-score 0.53
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62155
- Every structure of UniProt P78352
- Elsewhere: RCSB PDB 2MES · PDBe 2MES · UniProt P62155 · UniProt P78352
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.