UniProt P78352
Disks large homolog 4 (P78352)
Disks large homolog 4 (UniProt P78352): 28 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 9 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P78352
- Protein
- Disks large homolog 4
- Experimental structures
- 28
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 9 · 2 records with a druggable one
Structures
29 records of P78352 in the MolNFT archive: 28 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1KEF | PDZ1 of SAP90 | solution nmr | A | — | — |
| 1KEF | PDZ1 of SAP90 | solution nmr | A | — | — |
| 2MES | Backbone 1H, 13C, 15N resonance assignments of calcium-bound calmodulin in complex with PSD95… | solution nmr | B | — | — |
| 2MES | Backbone 1H, 13C, 15N resonance assignments of calcium-bound calmodulin in complex with PSD95… | solution nmr | B | — | — |
| 3I4W | Crystal Structure of the third PDZ domain of PSD-95 | x-ray diffraction | A, B, C, D | — | — |
| 3I4W | Crystal structure of the third PDZ domain of psd-95 | x-ray diffraction | A, B, C, D | — | — |
| 3K82 | Crystal Structure of the third PDZ domain of PSD-95 | x-ray diffraction | A | — | — |
| 3K82 | Crystal structure of the third PDZ domain of psd-95 | x-ray diffraction | A | — | — |
| 3ZRT | Crystal structure of human PSD-95 PDZ1-2 | x-ray diffraction | A, B, C, D | — | — |
| 3ZRT | Crystal structure of human psd-95 PDZ1-2 | x-ray diffraction | A, B, C, D | — | — |
| 5J7J | NMR Derived Structure of Ca2+ Calmodulin bound to Phosphorylated PSD-95 | solution nmr | B | — | — |
| 5J7J | NMR derived structure of CA2+ calmodulin bound to phosphorylated psd- 95 | solution nmr | B | — | — |
| 5JXB | PSD-95 extended PDZ3 in complex with SynGAP PBM | x-ray diffraction | A, C | — | — |
| 5JXB | Psd-95 extended PDZ3 in complex with syngap pbm | x-ray diffraction | A, C | — | — |
| 6QJD | Crystal Structure of the truncated form of the third PDZ domain of PSD-95: residues 302-392 | x-ray diffraction | A, B, C, D | SO4 | 5 (best 0.80) |
| 6QJD | Crystal structure of the truncated form of the third PDZ domain of psd-95: residues 302-392 | x-ray diffraction | A, B, C, D | SO4 | — |
| 6QJF | Crystal Structure of the third PDZ domain of PSD-95 protein D332P mutant: space group C121… | x-ray diffraction | A, B, C, D | — | 4 (best 0.64) |
| 6QJF | Crystal structure of the third PDZ domain of psd-95 protein D332P mutant: space group C121… | x-ray diffraction | A, B, C, D | — | — |
| 6QJG | Crystal structure of the third PDZ domain of psd-95 protein D332P mutant: space group C121… | x-ray diffraction | A, B, C, D | — | — |
| 6QJI | Crystal structure of the third PDZ domain of psd-95 protein: space group P3112 | x-ray diffraction | A, B, C, D, E, F | SO4 | — |
| 6QJJ | Crystal structure of the third PDZ domain of psd-95 protein: space group P3221 | x-ray diffraction | A | SO4 | — |
| 6QJK | Crystal Structure of the third PDZ domain of PSD-95 protein D332G mutant: space group P43 | x-ray diffraction | A | SO4 | — |
| 6QJK | Crystal structure of the third PDZ domain of psd-95 protein D332G mutant: space group P43 | x-ray diffraction | A | SO4 | — |
| 6QJL | Crystal structure of the third PDZ domain of psd-95 protein D332G mutant: space group P21 | x-ray diffraction | A, B | SO4 | — |
| 6QJN | Crystal structure of the third PDZ domain of psd-95 protein D332G mutant: space group I4122 | x-ray diffraction | A, B | — | — |
| 6SPV | Crystal structure of PDZ1-2 from psd-95 | x-ray diffraction | A | GSH | — |
| 6SPZ | Crystal structure of PDZ1-2 from PSD-95 with peptide ligand sequence RRESEI bound to both domains | x-ray diffraction | A | GSH | — |
| 6SPZ | Crystal structure of PDZ1-2 from psd-95 with peptide ligand sequence rresei bound to both domains | x-ray diffraction | A | GSH | — |
| P78352 | AlphaFold monomer V2.0 prediction for disks large homolog 4 (P78352) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6QJI chain C against the predicted model P78352: TM-score 0.98, RMSD 0.52 Å
- 6QJI chain D against the predicted model P78352: TM-score 0.98, RMSD 0.52 Å
- 6QJJ chain A against the predicted model P78352: TM-score 0.98, RMSD 0.53 Å
- 6QJI chain E against the predicted model P78352: TM-score 0.98, RMSD 0.57 Å
- 6QJI chain A against the predicted model P78352: TM-score 0.98, RMSD 0.55 Å
- 6QJI chain B against the predicted model P78352: TM-score 0.97, RMSD 0.65 Å
- 6QJI chain F against the predicted model P78352: TM-score 0.97, RMSD 0.70 Å
- 6QJN chain B against the predicted model P78352: TM-score 0.96, RMSD 0.80 Å
- 6QJK chain A against the predicted model P78352: TM-score 0.96, RMSD 0.93 Å
- 6QJK chain A against the predicted model P78352: TM-score 0.96, RMSD 0.93 Å
Elsewhere
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