Research workbench
The complex between ca-calmodulin and skeletal muscle myosin light chain kinase from combination of NMR and aqueous and contrast-matched saxs data
Analyse The complex between ca-calmodulin and skeletal muscle myosin light chain kinase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2LV6
- Type
- protein
- Length
- 174 residues
- Chains
- 2
- Method
- solution scattering; solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calmodulin; Myosin light chain kinase 2, SKELETAL/CARDIAC muscle
- EC
- 2.7.11.18
- UniProt
- P62158, Q9H1R3
- Ligands
- CA
- Pockets
- 2 · best druggability 0.48
Structure
solution scattering; solution nmr · 2 distinct chains · 60% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calmodulin | protein | 148 | 59% helix, 5% strand | P62158 |
| B | Myosin light chain kinase 2, SKELETAL/CARDIAC muscle (EC 2.7.11.18) | protein | 26 | 62% helix, 0% strand | Q9H1R3 |
Ligands and binding sites
- CA · Calcium ion · metal · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 116 | 0.48 | 0.80 | 19 | empty |
| 2 | 53 | 0.35 | 0.79 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1518 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 2LV6 · The complex between Ca-Calmodulin and skeletal muscle myosin light chain kinase from… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9H1R3 · AlphaFold monomer V2.0 prediction for myosin light chain kinase 2, SKELETAL/CARDIAC… · a predicted model of the same protein · chain B against A, TM-score 0.54
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62158
- Every structure of UniProt Q9H1R3
- Elsewhere: RCSB PDB 2LV6 · PDBe 2LV6 · UniProt P62158 · UniProt Q9H1R3
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.