Research workbench
The protein complex for DNA replication
Analyse The protein complex for DNA replication in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2LE8
- Type
- protein
- Length
- 143 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA replication licensing factor MCM6; DNA replication factor CDT1
- UniProt
- Q14566, Q9H211
- Pockets
- 1 · best druggability 0.52
Structure
solution nmr · 2 distinct chains · 48% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA replication licensing factor MCM6 | protein | 114 | 46% helix, 4% strand | Q14566 |
| B | DNA replication factor CDT1 | protein | 29 | 52% helix, 0% strand | Q9H211 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 138 | 0.52 | 0.80 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 656 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 2LE8 · The protein complex for DNA replication · the same entry in another collection · chain A against A, TM-score 1.00
- Q14566 · AlphaFold monomer V2.0 prediction for DNA replication licensing factor MCM6 (Q14566) · a predicted model of the same protein · chain A against A, TM-score 0.63
- Q9H211 · AlphaFold monomer V2.0 prediction for DNA replication factor CDT1 (Q9H211) · a predicted model of the same protein · chain B against A, TM-score 0.42
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14566
- Every structure of UniProt Q9H211
- Elsewhere: RCSB PDB 2LE8 · PDBe 2LE8 · UniProt Q14566 · UniProt Q9H211
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