UniProt Q14566
DNA replication licensing factor MCM6 (Q14566)
DNA replication licensing factor MCM6 (UniProt Q14566), EC 3.6.4.12: 17 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 90 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q14566
- Protein
- DNA replication licensing factor MCM6
- EC
- 3.6.4.12
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 90 · 11 records with a druggable one
Structures
18 records of Q14566 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2KLQ | The solution structure of CBD of human MCM6 | solution nmr | A | — | — |
| 2KLQ | The solution structure of cbd of human MCM6 | solution nmr | A | — | — |
| 2LE8 | The protein complex for DNA replication | solution nmr | A | — | — |
| 2LE8 | The protein complex for DNA replication | solution nmr | A | — | — |
| 6XTX | CryoEM structure of human CMG bound to ATPgammaS and DNA | electron microscopy | 6 | ADP, AGS, ZN, MG | 9 (best 0.85) |
| 6XTX | Cryoem structure of human cmg bound to atpgammas and DNA | electron microscopy | 6 | ADP, AGS, ZN, MG | — |
| 6XTY | Cryoem structure of human cmg bound to and-1 (cmga) | electron microscopy | 6 | ZN | — |
| 7PLO | H. sapiens replisome-CUL2/LRR1 complex | electron microscopy | 6 | MG, ANP, ZN | 7 (best 0.86) |
| 8S09 | H. sapiens MCM2-7 double hexamer bound to double stranded DNA | electron microscopy | 6, E | ATP, ADP, MG, ZN | 10 (best 0.89) |
| 8S0A | H. sapiens MCM2-7 hexamer bound to double stranded DNA | electron microscopy | 6 | ATP, ADP, MG, ZN | 9 (best 0.84) |
| 8S0B | H. sapiens MCM bound to double stranded DNA and ORC6 as part of the MCM-ORC complex | electron microscopy | 6 | AGS, MG, ZN | 7 (best 0.86) |
| 8S0D | H. sapiens MCM bound to double stranded DNA and ORC1-6 | electron microscopy | 6 | AGS, MG, ZN | 8 (best 0.87) |
| 8S0E | H. sapiens OCCM bound to double stranded DNA | electron microscopy | 6 | AGS, MG | 7 (best 0.85) |
| 8S0F | H. sapiens OC1M bound to double stranded DNA | electron microscopy | 6 | AGS, MG | 5 (best 0.85) |
| 8W0E | Cryo-EM structure of a human MCM2-7 single hexamer on dsDNA | electron microscopy | 6 | ATP, ZN, MG, ADP | 9 (best 0.88) |
| 8W0F | Cryo-EM structure of a human MCM2-7 double hexamer on dsDNA | electron microscopy | 6, E | ATP, ZN, MG, ADP | 13 (best 0.88) |
| 8W0I | Cryo-EM structure of the human MCM2-7 heterohexamer | electron microscopy | 6 | MG, ATP, ZN | 6 (best 0.88) |
| Q14566 | AlphaFold monomer V2.0 prediction for DNA replication licensing factor MCM6 (Q14566) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8W0I chain 6 against the predicted model Q14566: TM-score 0.90, RMSD 2.93 Å
- 8W0E chain 6 against the predicted model Q14566: TM-score 0.84, RMSD 3.90 Å
- 8S0E chain 6 against the predicted model Q14566: TM-score 0.82, RMSD 2.61 Å
- 8S0F chain 6 against the predicted model Q14566: TM-score 0.82, RMSD 2.62 Å
- 8W0F chain 6 against the predicted model Q14566: TM-score 0.82, RMSD 4.08 Å
- 6XTY chain 6 against the predicted model Q14566: TM-score 0.81, RMSD 4.50 Å
- 8S0B chain 6 against the predicted model Q14566: TM-score 0.79, RMSD 4.42 Å
- 8S0D chain 6 against the predicted model Q14566: TM-score 0.79, RMSD 4.44 Å
- 6XTX chain 6 against the predicted model Q14566: TM-score 0.79, RMSD 4.19 Å
- 6XTX chain 6 against the predicted model Q14566: TM-score 0.79, RMSD 4.19 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.